290809-98-2

Upstream product

• 208989-10-0 4-(p-fluorophenyl)-1-methyl-3-pyridiniumolate 
• 208989-15-5 (1S,5S,6R,R_S)-3-(p-fluorophenyl)-N-methyl-6-(p-tolylsulfinyl)-8-azabicyclo<3.2.1>oct-3-en-2-one 
• 54828-68-1 (R)-p-tolyl vinyl sulfoxide 
• 208989-21-3 (1S,5S,6R,R_S)-3α-(p-fluorophenyl)-N-methyl-4β-n-propyl-6β-(p-tolylsulfinyl)-8-azabicyclo<3.2.1>octan-2-one 

Downstream Products

• 290810-02-5 (1S,2S,3R,5R,7R)-7-Fluoro-3-(4-fluoro-phenyl)-8-methyl-2-propyl-7-(toluene-4-sulfonyl)-8-aza-bicyclo[3.2.1]octane 
• 290809-99-3 (1S,2S,3R,5R,7R)-3-(4-Fluoro-phenyl)-8-methyl-2-propyl-7-(toluene-4-sulfonyl)-8-aza-bicyclo[3.2.1]octane 
• 290810-01-4 (1R,3R,4S,5S,6S)-3-(4-Fluoro-phenyl)-8-methyl-4-propyl-8-aza-bicyclo[3.2.1]octan-6-ol 
• 290810-00-3 (1R,3R,4S,5S)-3-(4-Fluoro-phenyl)-8-methyl-4-propyl-8-aza-bicyclo[3.2.1]octan-6-one 
• 208989-26-8 (1S,5S,7R,R_S)-3α-(p-fluorophenyl)-2β-n-propyl-7β-(p-tolylsulfinyl)tropane 

Relevant academic research and scientific papers

An enantioselective synthesis and biobehavioral evaluation of 7-fluoro-3-(p-fluorophenyl)-2-propyltropanes

Optically pure 7-fluorotropanes 3a-c, were synthesized as structural probes of the dopamine transporter. The synthesis of these compounds was accomplished through the asymmetric 1,3-dipolar cycloaddition reaction of the oxidopyridinium betaine 4 with the chiral dipolarophile (R)-p-tolyl vinyl sulfoxide. In the preliminary analysis, tropane 3a was found to reduce the rewarding effects of cocaine in the brain stimulation reward paradigm. (C) 2000 Elsevier Science Ltd. All rights reserved.