208989-27-9

Upstream product

• 85506-18-9 (1R)-(-)-2-carbomethoxy-3-tropinone 
• 168143-65-5 methyl (1R,5S)-8-methyl-3-(((trifluoromethyl)sulfonyl)oxy)-8-azabicyclo[3.2.1]oct-2-ene-2-carboxylate 
• 220455-69-6 (R)-3-(4-methylphenyl)-2-tropinone 
• 220455-67-4 (1R)-3-(4-methylphenyl)trop-2-ene-2-carboxylic acid methyl ester 
• 220455-68-5 (1R,5S)-2-Isocyanato-8-methyl-3-p-tolyl-8-aza-bicyclo[3.2.1]oct-2-ene 
• 220455-71-0 3-(4-methylphenyl)-2-phenyl-tropene 
• 220455-73-2 (R)-N-phenoxycarbonyl-2-phenyl-3-(4methylphenyl)-2-tropene 
• 218146-32-8 thiocarbonic acid O-[8-methyl-4-phenyl-6-(toluene-4-sulfinyl)-3-p-tolyl-8-aza-bicyclo[3.2.1]oct-2-yl] ester O-phenyl ester 
• 218146-31-7 (1S,3R,4R,5S,6R)-8-Methyl-4-phenyl-6-((R)-toluene-4-sulfinyl)-3-p-tolyl-8-aza-bicyclo[3.2.1]octan-2-ol 
• 208989-17-7 (1S,5S,6R,R_S)-N-methyl-4β-phenyl-6β-(p-tolylsulfinyl)-3α-p-tolyl-8-azabicyclo<3.2.1>octan-2-one 
• 208989-23-5 (1S,5S,7R,R_S)-2β-phenyl-7β-(p-tolylsulfinyl)-3α-p-tolyltropane 
• 208989-13-3 (1S,5S,6R,R_S)-N-methyl-6-(p-tolylsulfinyl)-3-p-tolyl-8-azabicyclo<3.2.1>oct-3-en-2-one 
• 208989-08-6 1-methyl-4-p-tolyl-3-pyridiniumolate 
• 74-83-9 methyl bromide 

Relevant academic research and scientific papers

Synthesis and monoamine transporter binding properties of 2,3-diaryltropanes

Synthetic procedures were developed for the synthesis of 2β,3β- and 2α,3α-diaryltropanes. These compounds are analogues of the 3-aryltropane-2β-carboxylic acid methyl ester class of monoamine uptake inhibitors, where the 2β-carbomethoxy group has been rep

Tropane derivatives and method for their synthesis

A compound of formula (I) wherein R1-R6have any of the values defined in the specification are described, as well as pharmaceutical compositions comprising a compound of formula (I), and methods for preparing and using compounds of f

N-phenylalkyl-substituted tropane analogs of boat conformation with high selectivity for the dopamine versus serotonin transporter

A series of N-phenylalkyl-substituted tropane analogs of boat conformation was synthesized, and these tropanes were evaluated for their ability to inhibit high affinity uptake of dopamine (DA) and serotonin (5HT) into striatal nerve endings (synaptosomes). Some of these compounds exhibit high affinity for the DA transporter with a 5-HT/DA transporter selectivity ratio of >50.

Synthesis and biological properties of new 2β-alkyl- and 2β-aryl-3- (substituted phenyl)tropane derivatives: Stereochemical effect of C-3 on affinity and selectivity for neuronal dopamine and serotonin transporters

In our efforts to identify molecules that might act as cocaine antagonists or cocaine partial agonists, we have been involved in efforts to further elucidate the nature of cocaine's binding to the dopamine transporter (DAT) through strategic modifications

Synthesis and transporter binding properties of (R)-2β,3β- and (R)- 2α,3α-diaryltropanes

(R)-2-Aryl-2-tropinone (9) was synthesized from (R)-2-carbomethoxy-3- tropinone (5) and was used as the key intermediate for the synthesis of (R)- 2β,3β- and (R)-2α-3α-diaryltropanes. Inhibition of radioligand binding studies at the dopamine, serotonin, a