220455-67-4Relevant academic research and scientific papers
Synthesis and monoamine transporter binding properties of 2,3-diaryltropanes
Kotturi, Sharadsrikar V.,Jiang, Songchun,Chang, An-Chih,Abraham, Philip,Navarro, Hernán A.,Kuhar, Michael J.,Carroll, F. Ivy
, p. 7437 - 7444 (2007/10/03)
Synthetic procedures were developed for the synthesis of 2β,3β- and 2α,3α-diaryltropanes. These compounds are analogues of the 3-aryltropane-2β-carboxylic acid methyl ester class of monoamine uptake inhibitors, where the 2β-carbomethoxy group has been rep
Synthesis and transporter binding properties of (R)-2β,3β- and (R)- 2α,3α-diaryltropanes
Jiang, Songchun,Chang, An-Chih,Abraham, Philip,Kuhar, Michael J.,Carroll, F. Ivy
, p. 3689 - 3692 (2007/10/03)
(R)-2-Aryl-2-tropinone (9) was synthesized from (R)-2-carbomethoxy-3- tropinone (5) and was used as the key intermediate for the synthesis of (R)- 2β,3β- and (R)-2α-3α-diaryltropanes. Inhibition of radioligand binding studies at the dopamine, serotonin, a
