208997-79-9

Basic information

• Product Name: 2-Benzyloxycarbonylamino-4-(dimethoxy-phosphoryl)-butyric acid methyl ester
• Synonyms: 2-Benzyloxycarbonylamino-4-(dimethoxy-phosphoryl)-butyric acid methyl ester
• CAS NO: 208997-79-9
• Molecular Weight: 359.316
• Mol File: 208997-79-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Benzyloxycarbonylamino-4-(dimethoxy-phosphoryl)-butyric acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Benzyloxycarbonylamino-4-(dimethoxy-phosphoryl)-butyric acid methyl ester(208997-79-9)
• EPA Substance Registry System: 2-Benzyloxycarbonylamino-4-(dimethoxy-phosphoryl)-butyric acid methyl ester(208997-79-9)

Safety Data

• Hazardous Substances Data: 208997-79-9(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 155179-92-3 2-(N-benzyloxycarbonylamino)-4-phosphonobutanoic acid 

Downstream Products

• 208997-95-9 DL-methyl N,N-diethyl-{3-[(benzyloxycarbonyl)amino]-3-methoxycarbonylpropyl}-SR-phosphonamidate 
• 208997-91-5 DL-methyl N,N-dimethyl-{3-[(benzyloxycarbonyl)amino]-3-methoxycarbonylpropyl}-SR-phosphonamidate 
• 208997-93-7 DL-methyl N-ethyl-{3-[(benzyloxycarbonyl)amino]-3-methoxycarbonylpropyl}-SR-phosphonamidate 
• 208997-89-1 DL-methyl {3-[(benzyloxycarbonyl)amino]-3-methoxycarbonylpropyl}-SR-phosphonamidate 
• 208997-82-4 methyl hydrogen (RS) 3-(benzyloxycarbonylamino)-3-(methoxycarbonyl)-propylphosphonate 

Relevant articles and documents

Investigation of mechanism of nitrogen transfer in glucosamine 6- phosphate synthase with the use of transition state analogs

Several structural analogs of putative tetrahedral intermediates of the reaction catalyzed by the glutamine amide transfer domain of Candida albicans glucosamine 6-phosphate synthase have been designed and synthesized. Esters and amides of γ-phosphonic and γ-sulfonic analogs of glutamine and glutamic acid were tested as potential inhibitors of the enzyme. N-substituted amides 9 and 15 were found to be the strongest inhibitors in the series. Structure- activity relationship studies led to conclusions supporting the possibility of a direct nucleophilic attack of the glutamine amide nitrogen on an electrophilic site of the enzyme-bound fructose 6-phosphate as the most likely mechanism of nitrogen transfer in glucosamine 6-phosphate synthase.