20901-69-3

Usage

Uses

Used in Pharmaceutical Industry:
3-Fluoro-4-(methylthio)benzenamine is used as a chemical intermediate for the synthesis of pharmaceuticals, contributing to the development of new drugs. Its unique structure allows for the creation of molecules with specific therapeutic properties, making it valuable in medicinal chemistry.
Used in Dye Industry:
In the dye industry, 3-Fluoro-4-(methylthio)benzenamine is utilized as an intermediate in the production of dyes. Its aromatic amine structure and functional groups enable the creation of dyes with particular color characteristics and properties, suitable for various applications.
Used in Agrochemical Industry:
3-Fluoro-4-(methylthio)benzenamine is employed as a precursor in the synthesis of agrochemicals. Its chemical properties make it suitable for the development of compounds used in agriculture to protect crops and enhance yields.
Used in Material Science:
3-Fluoro-4-(methylthio)benzenamine is also used in material science for the development of new materials. Its unique structure and properties can be leveraged to create materials with specific characteristics, such as improved stability or reactivity, for various applications in different industries.

Upstream product

• 372-19-0 meta-fluoroaniline 
• 67-68-5 dimethyl sulfoxide 
• 372121-91-0 (2-fluoro-4-nitrophenyl)(methyl)sulfone 

Downstream Products

• 13333-79-4 3-fluoro-4-(methylthio)phenol 
• 1588945-01-0 4-((1S,2S)-2-(2-(3-fluoro-4-(methylsulfonyl)phenoxy)ethyl)cyclopropyl)piperidine 
• 1588945-00-9 benzyl 4-((1S,2S)-2-(2-(3-fluoro-4-(methylsulfonyl)phenoxy)ethyl)cyclopropyl)piperidine-1-carboxylate 
• 1447121-20-1 N-(2-(3-fluoro-4-(methylsulfonyl)phenoxy)ethyl)-1-(3-isopropyl-1,2,4-oxadiazol-5-yl)-N-methylpiperidine-4-amine trifluoroacetate 
• 1447121-17-6 N-(2-(3-fluoro-4-(methylsulfonyl)phenoxy)ethyl)-1-(3-isopropyl-1,2,4-oxadiazol-5-yl)-N-methylpiperidine-4-amine 

Relevant academic research and scientific papers

Highly regioselective para-methylthiolation/bridging methylenation of arylamines promoted by NH4I

Aryl methyl thioethers and methylene-bridged arylamines were synthesized via highly regioselective para-methylthiolation/bridging methylenation of arylamines using DMSO as the methylthio or methylene source in the presence of NH4I under metal-free conditions. For the substrates with both electron-donating and electron-withdrawing substituents, the reaction proceeded smoothly and gave moderate to good yields.

ARYL SUBSTITUTED HETEROCYCLYL SULFONES

The invention relates to aryl substituted heterocyclyl sulfones as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

SUBSTITUTED CYCLOPROPYL COMPOUNDS

Substituted cyclopropyl piperidinyl compounds and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-1 19. Pharmaceutical compositions and methods of treatment are also included.

SUBSTITUTED PIPERIDINE DERIVATIVES AND METHODS FOR PREPARING THE SAME

The present invention relates to a novel compound or a pharmaceutically acceptable salt thereof, a preparation method thereof and a pharmaceutical composition for treating metabolism-related disorder containing the same. Specifically, the present invention relates to a compound of the formula 1, which can activate GPR119 to treat metabolism-related disorders, including diabetes and related diseases, diabetes-related microvascular complications, diabetes-related macrovascular complications, cardiovascular abnormalities, metabolic syndrome and its constituent diseases, and obesity.

GPR119 Receptor Agonists

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.

1,2,4-triazole derivative, method for preparing the same, and pharmaceutical composition containing the same

A 1,2,4-triazole derivative of formula 1 or a non-toxic salt thereof, a preparation method thereof, and a pharmaceutical composition containing the derivative or the salt as an active ingredient are provided: wherein, Ar represents naphthyl; 3,4-methylene

1,2,4-TRIAZOLE DERIVATIVE, METHOD FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

A 1,2,4-triazole derivative of formula 1 or a non-toxic salt thereof, a preparation method thereof, and a pharmaceutical composition containing the derivative or the salt as an active ingredient are provided.