20901-69-3

Basic information

• Product Name: 3-Fluoro-4-(methylthio)benzenamine
• Synonyms: 3-Fluoro-4-(methylthio)benzenamine;3-FLUORO-4-(METHYLTHIO)ANILINE
• CAS NO: 20901-69-3
• Molecular Formula: C₇H₈FNS
• Molecular Weight: 157
• Mol File: 20901-69-3.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Fluoro-4-(methylthio)benzenamine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Fluoro-4-(methylthio)benzenamine(20901-69-3)
• EPA Substance Registry System: 3-Fluoro-4-(methylthio)benzenamine(20901-69-3)

Safety Data

• Hazardous Substances Data: 20901-69-3(Hazardous Substances Data)

Usage

General Description

3-Fluoro-4-(methylthio)benzenamine, also known as 4-Fluoro-3-(methylthio)aniline, is a chemical compound with the molecular formula C7H7F1N1S1. This aromatic amine features a fluorine atom and a methylthio group attached to a benzene ring. It is commonly used as an intermediate in the synthesis of pharmaceuticals, dyes, and agrochemicals. The compound has been studied for its potential applications in the development of new drugs and materials. Additionally, it is important to handle this chemical with proper care due to its potential health hazards and toxic effects.

Upstream product

• 372-19-0 meta-fluoroaniline 
• 67-68-5 dimethyl sulfoxide 
• 372121-91-0 (2-fluoro-4-nitrophenyl)(methyl)sulfone 

Downstream Products

• 13333-79-4 3-fluoro-4-(methylthio)phenol 
• 1588945-01-0 4-((1S,2S)-2-(2-(3-fluoro-4-(methylsulfonyl)phenoxy)ethyl)cyclopropyl)piperidine 
• 1588945-00-9 benzyl 4-((1S,2S)-2-(2-(3-fluoro-4-(methylsulfonyl)phenoxy)ethyl)cyclopropyl)piperidine-1-carboxylate 
• 1447121-20-1 N-(2-(3-fluoro-4-(methylsulfonyl)phenoxy)ethyl)-1-(3-isopropyl-1,2,4-oxadiazol-5-yl)-N-methylpiperidine-4-amine trifluoroacetate 
• 1447121-17-6 N-(2-(3-fluoro-4-(methylsulfonyl)phenoxy)ethyl)-1-(3-isopropyl-1,2,4-oxadiazol-5-yl)-N-methylpiperidine-4-amine 

Relevant articles and documents

Highly regioselective para-methylthiolation/bridging methylenation of arylamines promoted by NH4I

Aryl methyl thioethers and methylene-bridged arylamines were synthesized via highly regioselective para-methylthiolation/bridging methylenation of arylamines using DMSO as the methylthio or methylene source in the presence of NH4I under metal-free conditions. For the substrates with both electron-donating and electron-withdrawing substituents, the reaction proceeded smoothly and gave moderate to good yields.

SUBSTITUTED CYCLOPROPYL COMPOUNDS

Substituted cyclopropyl piperidinyl compounds and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-1 19. Pharmaceutical compositions and methods of treatment are also included.

GPR119 Receptor Agonists

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.