20920-99-4

Basic information

• Product Name: 6-nitro-3,4-dihydro-2H-chromen-2-one
• Synonyms: 2H-1-benzopyran-2-one, 3,4-dihydro-6-nitro-; 3,4-dihydro-6-nitrocoumarin; 6-Nitro-2-chromanone; 6-Nitrochroman-2-one
• CAS NO: 20920-99-4
• Molecular Formula: C₉H₇NO₄
• Molecular Weight: 193.1562
• Mol File: 20920-99-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 371°C at 760 mmHg
• Flash Point: 192.6°C
• Density: 1.424g/cm³
• Vapor Pressure: 1.06E-05mmHg at 25°C
• Refractive Index: 1.604
• CAS DataBase Reference: 6-nitro-3,4-dihydro-2H-chromen-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-nitro-3,4-dihydro-2H-chromen-2-one(20920-99-4)
• EPA Substance Registry System: 6-nitro-3,4-dihydro-2H-chromen-2-one(20920-99-4)

Safety Data

• Hazardous Substances Data: 20920-99-4(Hazardous Substances Data)

Upstream product

• 119-84-6 C₆H₄(CH₂CH₂C(O)O) 

Downstream Products

• 54892-99-8 3-(2-hydroxy-5-nitrophenyl)propanoic acid 

Relevant articles and documents

3,4-Dihydro-3-methyl-6-nitro-2H-1,3-benzoxazin-2-one, a Reagent for Labeling p-Nitrophenyl Esterases with a Chromophoric Reporter Group - Synthesis and Reaction with Chymotrypsin

We reported the synthesis of 3,4-dihydro-3-methyl-6-nitro-2H-1,3-benzoxazin-2-one (DMNB), a close structural anlogue of p-nitrophenyl dimethylcarbamate.DMNB is unstable in aqueous solution when exposed to light, but is stable in the dark.The compound reac

Design, synthesis and in vitro pharmacology of GluK1 and GluK3 antagonists. Studies towards the design of subtype-selective antagonists through 2-carboxyethyl-phenylalanines with substituents interacting with non-conserved residues in the GluK binding sites

In order to identify compounds selective for the GluK1 and GluK3 subtypes of kainate receptors we have designed and synthesized a series of (S)-2-amino-3-((2-carboxyethyl)phenyl)propanoic acid analogs with hydrogen bond donating and accepting substituents on the aromatic ring. Based on crystal structures of GluK1 in complex with related ligands, the compounds were designed to explore possible interactions with non-conserved residues outside the glutamate ligand binding site and challenge the water binding network. Apart from obtaining GluK1 selective antagonists one analog with a phenyl-substituted urea (compound 31) showed some preference for GluK3 over GluK1-receptors. Docking studies indicate that this preference may be attributed to contacts between the NH of the urea substituent and non-conserved Ser741 and Ser761 residues.