209223-34-7

Upstream product

• 73259-81-1 (R)-2-tert-butoxycarbonyl-3-aminopropionic acid 
• 1493-27-2 ortho-nitrofluorobenzene 
• 209223-32-5 (R)-(-)-2-tert-butoxycarbonylamino-3-(2-nitrophenylamino)propionic acid 
• 209223-33-6 (R)-(+)-2-oxo-3-tert-butoxycarbonylamino-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine 
• 1521-51-3 rac-3-bromocyclohexene 

Downstream Products

• 252209-91-9 (R)-(-)-2-oxo-3-tert-butoxycarbonylamino-5-cyclohexyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine 

Relevant academic research and scientific papers

1,5-benzodiazepine derivatives

This invention relates to 1,5-benzodiazepine derivatives, which are each represented by the following formula (1): wherein R1represents a lower alkyl group, R2and R3may be the same or different and represent a hydrogen atom or a lower alkyl group, R4represents a cyclohexyl group or phenyl group, and n stands for an integer of from 1 to 3, and also to medicines containing the same. These compounds are useful as curatives or preventives for diseases in which a gastrin receptor and/or a CCK-B receptor takes part.

1,5 Benzodiazepine derivatives

1,5-Benzodiazepine derivatives represented by formula (I), salts thereof, and medicines containing the same as the active ingredient: The compounds exhibit excellent gastrin and/or CCK-B receptor antagonism and are useful as remedies for gastric ulcer and gastrointestinal movement disorder.