20925-25-1

Basic information

• Product Name: 2-PYRROLIDIN-1-YLBENZONITRILE
• Synonyms: 2-PYRROLIDIN-1-YLBENZONITRILE;2-Pyrrolidin-1-ylbenzonitrile 95%;2-(1-pyrrolidinyl)Benzonitrile
• CAS NO: 20925-25-1
• Molecular Formula: C₁₁H₁₂N₂
• Molecular Weight: 172.23
• Mol File: 20925-25-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 321.5°C at 760 mmHg
• Flash Point: 141.9°C
• Appearance: /
• Density: 1.12g/cm³
• Vapor Pressure: 0.000297mmHg at 25°C
• Refractive Index: 1.588
• PKA: 5.68±0.20(Predicted)
• CAS DataBase Reference: 2-PYRROLIDIN-1-YLBENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PYRROLIDIN-1-YLBENZONITRILE(20925-25-1)
• EPA Substance Registry System: 2-PYRROLIDIN-1-YLBENZONITRILE(20925-25-1)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 20925-25-1(Hazardous Substances Data)

Usage

General Description

2-Pyrrolidin-1-ylbenzonitrile, also known as PB-22, is a synthetic cannabinoid that is structurally related to the psychoactive compound JWH-018. PB-22 acts as a potent agonist for the cannabinoid receptors CB1 and CB2, and it has been found to have similar effects to traditional cannabis, including psychoactive and sedative effects. Due to its psychoactive properties, PB-22 has been listed as a controlled substance in some countries, including the United States and the United Kingdom. Its use has been associated with numerous adverse effects, including hallucinations, tachycardia, and agitation, and its use is considered to be a potential public health concern.

InChI:InChI=1/C11H12N2/c12-9-10-5-1-2-6-11(10)13-7-3-4-8-13/h1-2,5-6H,3-4,7-8H2

Upstream product

• 123-75-1 pyrrolidine 
• 394-47-8 2-fluorobenzonitrile 
• 4787-77-3 2-(pyrrolidin-1-yl)phenol 
• 109-74-0 propyl cyanide 
• 2042-37-7 o-cyanobromobenzene 

Downstream Products

• 67829-47-4 2-(pyrrolidin-1-yl)benzamide 

Relevant articles and documents

Nickel-Catalyzed Amination of (Hetero)aryl Halides Facilitated by a Catalytic Pyridinium Additive

An efficient and operationally simple Ni-catalyzed amination protocol has been developed. This methodology features a simple NiII salt, an organic base and catalytic amounts of both a pyridinium additive and Zn metal. A diverse number of (hetero)aryl halides were coupled successfully with primary and secondary alkyl amines, and anilines in good to excellent yields. Similarly, benzophenone imine gave the corresponding N-arylation product in an excellent yield.

Nickel-Catalyzed Cyanation of Aryl Chlorides and Triflates Using Butyronitrile: Merging Retro-hydrocyanation with Cross-Coupling

We describe a nickel-catalyzed cyanation reaction of aryl (pseudo)halides that employs butyronitrile as a cyanating reagent instead of highly toxic cyanide salts. A dual catalytic cycle merging retro-hydrocyanation and cross-coupling enables the conversion of a broad array of aryl chlorides and aryl/vinyl triflates into their corresponding nitriles. This new reaction provides a strategically distinct approach to the safe preparation of aryl cyanides, which are essential compounds in agrochemistry and medicinal chemistry.

Substituted compounds derived from N-(benzyl)phenylacetamide, preparation and uses

This invention relates to poly-substituted derivatives of the N-(benzyl)phenylacetamide type, pharmaceutical compositions comprising same, therapeutic uses thereof, more particularly in the fields of human and animal health. This invention also relates to a process for the preparation of such derivatives.