209269-32-9Relevant academic research and scientific papers
Substrate specificity of human prolyl-4-hydroxylase
Tandon, Manish,Wu, Min,Begley, Tadhg P.,Myllyharju, Johanna,Pirskanen, Asta,Kivirikko, Kari
, p. 1139 - 1144 (2007/10/03)
Proline analogs (3-F, 3-Cl, 3-Br, 3,3-cyclopropyl, 3,3-methylene, 3-Me, and 4-Me) were synthesized, incorporated into CbzGlyPheXGlyOEt, and tested as substrate analogues/mechanistic probes for the human prolyl-4-hydroxylase catalyzed hydroxylation reaction. With the exception of the 3-fluoroproline containing peptide, none of these peptides were substrates for the enzyme.
