209268-98-4

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 209269-30-7 (R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-triisopropylsilanyloxy-pyrrolidine-1-carboxylic acid benzyl ester 
• 209269-32-9 (S)-3-Triisopropylsilanyloxy-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 
• 209269-31-8 (R)-2-Hydroxymethyl-3-triisopropylsilanyloxy-pyrrolidine-1-carboxylic acid benzyl ester 
• 209269-02-3 (S)-1-Benzenesulfonyl-2-(tert-butyl-dimethyl-silanyloxymethyl)-3-methylene-pyrrolidine 
• 209269-34-1 N-CBZ-L-hydroxyproline 
• 209269-00-1 (R)-1-Benzenesulfonyl-2-(tert-butyl-dimethyl-silanyloxymethyl)-pyrrolidin-3-one 

Relevant academic research and scientific papers

Substrate specificity of human prolyl-4-hydroxylase

Proline analogs (3-F, 3-Cl, 3-Br, 3,3-cyclopropyl, 3,3-methylene, 3-Me, and 4-Me) were synthesized, incorporated into CbzGlyPheXGlyOEt, and tested as substrate analogues/mechanistic probes for the human prolyl-4-hydroxylase catalyzed hydroxylation reaction. With the exception of the 3-fluoroproline containing peptide, none of these peptides were substrates for the enzyme.