2093-28-9Relevant academic research and scientific papers
Thyroid receptor ligands, pharmaceutical compositions comprising them and their use in the treatment of disorders influenced by thyroid hormones
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, (2008/06/13)
This invention relates to compounds of the formula (I) which are thyroid receptor ligands, and are preferably selective for the thyroid hormone receptor β, to methods of preparing such compounds and to methods for using such compounds such as in the regulation of metabolism.
A NOVEL, SIMPLE METHOD FOR THE PREPARATION OF HINDERED DIPHENYL ETHERS
Sammes, Peter G.,Thetford, Dean,Voyle, Martyn
, p. 3229 - 3232 (2007/10/02)
The displacement of the nitro group from substituted nitrobenzenes is used for the synthesis of diphenyl ethers. 1,4-Dinitrobenzene has been converted into a variety of hindered diphenyl ethers using 2,6-disubstituted phenoxides and studies show that the mechanism of formation of the ether (5a) is radical in nature.
Displacement of an Aromatic Nitro Group using Phenoxides
Sammes, P. G.,Thetford, D.,Voyle, M.
, p. 1373 - 1374 (2007/10/02)
1,4-dinitrobenzene undergoes nucleophilic substitution with sodium phenoxide and several hindered 2,6-disubstituted phenoxides to afford diphenyl ethers.
CHLOROSULFONATION OF SOME DIPHENYL DERIVATIVES
Cremlyn, Richard,Montgomery, Stephen,Ng, Yew,Simpson, David
, p. 341 - 352 (2007/10/02)
Benzophenone (1), diphenyl sulfone, and 4-nitro-2'-chloro- and 4-nitro-2',6'-dichlorophenyl ethers (23,24) have been chlorosulfonated.The direct yield of benzophenone-3,3'-disulfonyl chloride (2) was low, the majority of product was the disulfonic acid.Diphenyl sulfone (11) with a large amount of chlorosulfonic acid (8 mols) at 140 deg gave the 3,3'-disulfonyl chloride (12).With less reagent (6 mols) at 90 deg a mixture of the 3-sulfonyl chloride (21) and diphenyl sulfone was formed.Subsequent reaction with sodium azide gave the 3-sulfonyl azide (22).The diphenyl ether sulfonyl chlorides (25,26) were very susceptible to hydrolysis, especially (26) which probably accounts for the low yield obtained (31percent).The various sulfonyl chlorides were characterized as amides, azides, hydrazides and hydrazones (Tables I-III) and their i.r., n.m.r., and mass spectral data are included.
