209340-75-0Relevant academic research and scientific papers
Synthesis of [(2'S, 3'S)-bis(hydroxylmethyl)pyrrolidin-1-yl] purine and pyrimidine nucleosides as potential antiviral agents
Oohashi, Taketo,Nishiyama, Shigeru,Yamamura, Shosuke,Kato, Kuniki
, p. 1187 - 1188 (1998)
The enantiomerically pure synthesis of [(2'S, 3'S)- bis(hydroxymethyl)pyrrolidin-1-yl] thymine 17 and -adenine 20 was achieved via construction of the base on the 1-amino-pyrrolidine 15, and their anti- HSV-1 and -2, and anti-HIV-1 activities were evaluated.
