Bioorganic and Medicinal Chemistry Letters p. 1187 - 1188 (1998)
Update date:2022-07-30
Topics:
Oohashi, Taketo
Nishiyama, Shigeru
Yamamura, Shosuke
Kato, Kuniki
The enantiomerically pure synthesis of [(2'S, 3'S)- bis(hydroxymethyl)pyrrolidin-1-yl] thymine 17 and -adenine 20 was achieved via construction of the base on the 1-amino-pyrrolidine 15, and their anti- HSV-1 and -2, and anti-HIV-1 activities were evaluated.
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