Synthesis of [(2'S, 3'S)-bis(hydroxylmethyl)pyrrolidin-1-yl] purine and pyrimidine nucleosides as potential antiviral agents

DOI: 10.1016/S0960-894X(98)00193-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1187 - 1188 (1998)

Update date:2022-07-30

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Authors:

Oohashi, Taketo

Nishiyama, Shigeru

Yamamura, Shosuke

Kato, Kuniki

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Article abstract of DOI:10.1016/S0960-894X(98)00193-0

The enantiomerically pure synthesis of [(2'S, 3'S)- bis(hydroxymethyl)pyrrolidin-1-yl] thymine 17 and -adenine 20 was achieved via construction of the base on the 1-amino-pyrrolidine 15, and their anti- HSV-1 and -2, and anti-HIV-1 activities were evaluated.

Full text of DOI:10.1016/S0960-894X(98)00193-0

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