209344-13-8

Upstream product

• 636-98-6 p-nitrobenzene iodide 
• 1663-39-4 tert-Butyl acrylate 
• 100-00-5 4-chlorobenzonitrile 
• 555-16-8 4-nitrobenzaldehdye 
• 59159-39-6 (tert-butoxycarbonylmethyl)triphenylphosphonium bromide 
• 586-78-7 para-nitrophenyl bromide 

Downstream Products

• 162936-33-6 4-aminocinnamic acid tert-butyl ester 
• 131818-18-3 p-(N-tert-butoxycarbonyl)aminocinnamic acid 
• 1091595-69-5 p-(9-fluorenylmethoxycarbonylamino)-cinnamic acid 
• 2393-18-2 p-aminocinnamic acid 

Relevant academic research and scientific papers

Fabrication of Pd/CuFe2O4 hybrid nanowires: A heterogeneous catalyst for Heck couplings

The development of environmentally benign transformations is indispensable in organic synthesis. Herein, a hybrid heterogeneous catalyst, palladium(0) on copper ferrite nanowires, has been synthesized, characterized, and for the first time, employed in the Jeffrey Heck reaction between iodoarenes and allylic alcohols, and good to excellent yields have been obtained. In addition, the catalyst was found to be suitable for the usual Heck coupling. The nanocatalyst was recovered and reused up-to multiple runs without any noticeable loss of its catalytic activity.

RETRACTED ARTICLE: A Recycling-Free Nanocatalyst System: The Stabilization of in Situ-Reduced Noble Metal Nanoparticles on Silicone Nanofilaments via a Mussel-Inspired Approach

The recovery and reuse of costly nanocatalysts is an essential operation in modern nanocatalysis, and improvements in catalyst reusability can contribute significantly to the economic viability and sustainable development of nanocatalysis. Herein, starting with the application of a silicone nanofilament (SNF) coating on a target substrate, a mussel-inspired approach in the form of polydopamine (PDA) deposition on the SNF surface was used to form in situ-reduced Pd nanoparticles (Pd NPs) and to stabilize them on the SNFs. This PDA-mediated approach enabled a high integrity nanocatalyst system to be built on a free-standing SNF support while retaining the porosity in the original SNF architecture. The SNFs-Pd nanocomposites prepared as such were applied to the inside walls of laboratory chemical reactors and used as recycling-free nanocatalyst systems for Pd-catalyzed organic reactions without the laborious conventional catalyst recovery and redispersion processes. The SNFs-Pd catalyst system exhibited high activity and high selectivity in single and successive Heck coupling reactions; and a reusability as high as 90% was still possible in the 20th cycle. This mussel-inspired approach is highly versatile and can be applied to laboratory chemical reactors in different shapes, sizes, and configurations to scale up the nanocatalyst applications. Furthermore, the general utility of the chemistry involved allows this surface modification technique to apply to other supported noble metal (e.g., Ag, Au, and Pt) catalysts, thereby increasing the usability and the performance of nanocatalyst systems.

Poly(ethylene glycol) as reaction medium for mild Mizoroki-Heck reaction in a ball-mill

Phosphine-free palladium-catalyzed Mizoroki-Heck reaction was performed using ball-milling in polyethylene glycol under mild conditions. Good to excellent yields of coupling products were obtained. This activation technique also allowed the concomitant fo

Carbene based palladium-catalyzed Mizoroki-Heck reaction

Different perhydrobenzimidazolinium chloride salts were used as a ligand for PdcatalysedMizoroki-Heck reaction. The in situ generation of carbene is the attractive feature of this catalytic system. The corresponding Mizoroki-Heck products were obtained in good yield.

Syntheses and catalytic activities of Pd(II) dicarbene and hetero-dicarbene complexes

A series of palladium(II) complexes (1-6) bearing cis-chelating homo-dicarbene ligands with varying alkyl bridges (C1-C3) and N-heterocyclic backbones (imidazole and benzimidazole) have been synthesized by reaction of Pd(OAc)2 with the respective diazolium bromides (A·2HBr - F·2HBr) in DMSO. A comparative catalytic study employing aryl chlorides in the Mizoroki-Heck reaction revealed the superiority of methylene- and propylene-bridged dibenzimidazolin-2-ylidenes over their imidazole-derived analogues. Based on these results, two new propylene-bridged hetero-dicarbene complexes (7 and 8) were designed containing a mixed benzimidazole/imidazole- derived NHC-donor set. Notably, both complexes outperformed their homo-dicarbene analogues, which may be due to the electronic asymmetry induced by hetero-dicarbene ligands. The molecular structures of complex 6 and 8 are also presented.

Syntheses and catalytic activities of pseudo-pincer and CSC pincer-type Pd(II) complexes derived from benzannulated N-heterocyclic carbenes

Three new dibenzimidazolium salts bearing thioether (B·2HBr, B·2HNO3) and sulfoxide (C·2HBr) containing bridges have been synthesized as sulfur-functionalized dicarbene precursors. Palladation of B·2HBr and C·2HBr afforded two new pseudo-pincer

CINNAMOYL INHIBITORS OF TRANSGLUTAMINASE

A compound of Formula, (I) or Formula: (II)

Synthesis and characterization of dithia[3.3](2,6)pyridinophane-containing polymers: Application to the palladium-catalyzed Heck reaction

We synthesized zigzag polymers consisting of dithia[3.3](2,6)pyridinophane units that were flipped rapidly as a result of syn-[anti]-syn isomerization. Pyridinophane units were fixed in the syn form by complexation with palladium, and the resulting polyme

METHOD OF SYNTHESIZING COMPOUND

A method of synthesizing a compound through a coupling reaction using a palladium-containing perovskite-type composite oxide as a catalyst. The catalyst retains its activity even when recovered after the reaction and repeatedly used. The reaction can produce the target compound in high yield. In the Suzuki coupling reaction given by the following general formula (15), the palladium-containing perovskite-type composite oxide is used as a synthesis reaction catalyst and a reaction solvent comprising an alkoxyalcohol is used.