20939-16-6

Usage

Uses

Used in Organic Synthesis:
4-AMINO-5-ETHYL-4H-1,2,4-TRIAZOLE-3-THIOL, 97 is used as a key intermediate in organic synthesis for the production of a wide range of chemical compounds. Its unique structure allows it to participate in various chemical reactions, making it a valuable building block in the synthesis of complex organic molecules.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 4-AMINO-5-ETHYL-4H-1,2,4-TRIAZOLE-3-THIOL, 97 is used as an intermediate in the synthesis of various drugs. Its reactivity and functional groups enable the development of new pharmaceutical compounds with potential therapeutic applications.
Used in Agrochemical Production:
4-AMINO-5-ETHYL-4H-1,2,4-TRIAZOLE-3-THIOL, 97 is also utilized in the agrochemical sector as an intermediate for the synthesis of pesticides and other agrochemicals. Its unique properties allow for the creation of effective and targeted agrochemical products.
Used in Specialty Chemicals Manufacturing:
4-AMINO-5-ETHYL-4H-1,2,4-TRIAZOLE-3-THIOL, 97 is used as a building block in the production of specialty chemicals, which are used in various industries such as coatings, adhesives, and plastics. Its versatility and reactivity contribute to the development of high-performance specialty chemicals.
Used in Research and Development:
4-AMINO-5-ETHYL-4H-1,2,4-TRIAZOLE-3-THIOL, 97 is employed in research and development for exploring new chemical reactions and applications. Its unique structure and reactivity make it an interesting subject for scientific investigation and potential innovation.
Used in Dyes and Pigments Manufacturing:
In the dye and pigment industry, 4-AMINO-5-ETHYL-4H-1,2,4-TRIAZOLE-3-THIOL, 97 is used in the synthesis of various dyes and pigments. Its properties contribute to the development of vibrant and stable colorants for different applications.
Used in Materials Science:
4-AMINO-5-ETHYL-4H-1,2,4-TRIAZOLE-3-THIOL, 97 has potential applications in the field of materials science, where its unique structure and reactivity can be harnessed to develop new materials with specific properties for various applications.

InChI:InChI=1/C4H8N4S/c1-2-3-6-7-4(9)8(3)5/h2,5H2,1H3,(H,7,9)

Upstream product

• 802294-64-0 propionic acid 
• 2231-57-4 Thiocarbohydrazide 
• 6610-29-3 4-methylthiosemicarbazide 
• 75-15-0 carbon disulfide 
• 5818-15-5 d'hydrazide de l'acide propionique 
• 79-19-6 thiosemicarbazide 
• 90992-69-1 C₄H₇N₂OS₂^(1-)*K⁽¹⁺⁾ 

Downstream Products

• 24852-22-0 3-ethyl-6-phenyl-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole 
• 68469-04-5 7H-3-Ethyl-6-(p-diphenyl)-s-triazolo<3,4-b><1,3,4>thiadiazin 
• 24848-29-1 3-ethyl-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine 
• 139267-84-8 4-<5-(4-p-Nitrophenyl)-2-furfurylidene>amino-3-mercapto-5-ethyl-1,2,4-triazole 
• 139268-02-3 6-<5-(4-Nitrophenyl)-2-furyl>-3-ethyl-1,2,4-triazolo<3,4-b>-1,3,4-thiadiazole 
• 3176-52-1 6-amino-3-ethyl-s-triazolo-[3,4-b][1,3,4]thiadiazole 
• 139267-96-2 4-{[1-[5-(4-Chloro-phenyl)-furan-2-yl]-meth-(Z)-ylidene]-amino}-5-ethyl-2,4-dihydro-[1,2,4]triazole-3-thione 
• 69560-96-9 6-(4-chloro-phenyl)-3-ethyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine; monohydrobromide 
• 7271-45-6 2-mercapto-5-ethyl-1,3,4-triazole 
• 219611-90-2 4-(4-nitrobenzylideneamino)-5-mercapto-3-ethyl-4H-1,2,4-triazole 
• 119153-17-2 5-ethyl-4-(2-hydroxyphenylmethyleneamino)-3-mercapto-1,2,4-triazole 
• 150518-54-0 4-(N,N-dimethylbenzylideneamino)-5-mercapto-3-ethyl-4H-1,2,4-triazole 

Relevant academic research and scientific papers

Laccase Enzyme Catalysed Efficient Synthesis of 3-Substituted-1,2,4-Triazolo(4,3-b)(4,1,2)Benzothiadiazine-8-Ones

Full details of an efficient one step synthesis of substituted(4,3-b)(4,1,2)benzothiadiazine-8-ones (4a-4h) by Laccase enzyme (E.C.1.10.3.2) mediated reaction of various 5-substituted-4-amino-3-mercapto-1,2,4-triazoles (1a-1h) and hydroquinone (2) is desc

Synthesis, Antibacterial Activity, and Mechanisms of Novel 6-Sulfonyl-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole Derivatives

A series of novel 6-sulfonyl-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole derivatives were designed and synthesized. CoMFA models were established to analyze the quantitative structure-activity relationships on the basis of the EC50 values of the compounds. Th

Synthesis and characterization of novel Cu (II) complexes with 3-substituted-4-amino-5-mercapto-1,2,4-triazole Schiff bases: A new route to CuO nanoparticles

Cu (II) complexes, were synthesized with newly derived biologically active 1,2,4-triazole Schiff bases. The Schiff bases were synthesized by condensation of 3-substituted-4-amino-5-mercapto-1,2,4-triazole with dibenzoylmethane. The synthesized compounds were characterized using elemental analysis, magnetic moment, thermal analysis and spectral tools (FT-IR, 1HNMR, ESR, and UV-Vis spectroscopy). All the synthesized complexes are nonelectrolytes in N,N-dimethylformamide. The synthesized Schiff bases and their Cu (II) complexes have been screened for antibacterial (Escherichia coli & Staphylococcus aureus) and antifungal (Aspergillus flavus & Candida albicans) activity using a modified Bauer-Kirby method. Interestingly, the synthesized Cu (II) complexes were used as precursors for CuO nanoparticles which were characterized using XRD, HR-TEM, FT-IR and UV-Vis spectroscopy. The photocatalytic activity of the prepared CuO nanoparticles was studied by performing the degradation of methylene blue dye under UV illumination in the presence of H2O2 and the results showed that the maximum percent of the degradation of methylene blue dye (MB) was found 96.18% after 360 min.

Synthesis and Biological Evaluation of 1,2,4-Triazole Thioethers as Both Potential Virulence Factor Inhibitors against Plant Bacterial Diseases and Agricultural Antiviral Agents against Tobacco Mosaic Virus Infections

Targeting the virulence factors of phytopathogenic bacteria is an innovative strategy for alleviating or eliminating the pathogenicity and rapid outbreak of plant microbial diseases. Therefore, several types of 1,2,4-triazole thioethers bearing an amide l

1,2,4-triazole-3-thione Schiff bases compounds: Crystal structure, hirshfeld surface analysis, DFT studies and biological evaluation

Three novel Schiff base compounds (G1, G2 and G3) were synthesized and characterized by elemental analysis, FT-IR, NMR, and X-ray single crystal diffraction. The crystal structures exhibit both inter- and intra-molecular h

1,2,4-triazole thioether derivatives, and crystal structure and application thereof

The present invention discloses 1,2,4-triazole thioether derivatives having a structure represented by formula I, pharmaceutically acceptable salts, a crystal structure and a medicinal composition thereof, and an application of the derivatives in the prep

Synthesis and biological evaluation of some novel S-β-D-glucosides of 4-amino-5-alkyl-1,2,4-triazole-3-thiones derivatives

A novel series of 3-S-β-D-glucosides-4-arylideneamino-5-alkyl-1,2,4-triazoles were designed and synthesized by reaction of 4-amino-5-alkyl-4H-1,2,4triazole-3-thiol Schiff bases and 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide. The structures of the target compounds have been characterized by 1H NMR, 13C NMR, FT-IR, and Microanalyses. All the newly synthesized compounds have been screened for their in vitro antibacterial and antifungal activities against two Gram-positive bacteria [Bacillus cereus (PTCC 1015) and Staphylococcus aureus (ATCC 25923)], two Gram-negative bacteria [Pseudomonas aeruginosa (ATCC 27853) and Escherichia coli (PTCC 1399) and two fungi [Aspergillus Niger (PTCC 5012) and Candida albicans (PTCC 5027)].

Synthesis of Novel 1,2,4-Triazole-3-thione Derivatives as Influenza Neuraminidase Inhibitors

A series of 1,2,4-triazole-3-thione derivatives (6a–6t) were synthesized and evaluated against influenza viruses (H1N1) neuraminidase (NA) in vitro. Eighteen compounds exhibited inhibitory potency with IC50 values ranging from 14.68?±?0.49 to 39.85?±?4.23?μg/mL. Among them, compounds 6e and 6h showed significant inhibitory activity with IC50 values of 14.97?±?0.70 and 14.68?±?0.49?μg/mL, respectively. Structure activity relationships were established. Molecular docking studies were performed to understand the binding interaction between active compounds and NA.

Synthesis of novel 6-(1H-pyrazol-4-yl)-[1, 2, 4]triazolo[3, 4-b][1, 3, 4]thiadiazoles as potential antimicrobial agents

Background: Triazolothiadiazoles are molecules of great synthetic and pharmacological significance. They are associated with significant antimicrobial, antifungal, antibacterial, antihelmintic and anti-inflammatory activities. Method: The condensation of 5-alkyl-4-amino-3-mercapto-4H-1, 2, 4-triazoles with 3-aryl-1- phenylpyrazole-4-carboxylic acids was carried out in the presence of phosphoryl chloride and the resulting products were tested in vitro for their antibacterial potential against Bacillus subtilis (gram positive), Staphylococcus aureus (gram positive), Escherichia coli (gram negative) and Pseudomonas aeruginosa (gram negative) and further antifungal properties against Candida albicans, and Saccharomyces cervisiae. Results: A new series of 3-alkyl-6-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-[1, 2, 4]triazolo[3, 4-b][1, 3, 4] thiadiazoles has been synthesized by the reaction mentioned above. One specific compound, 6-(3-(4- fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-3-methyl-[1, 2, 4]triazolo[3, 4-b][1, 3, 4]thiadiazole displayed an excellent antifungal activity against Candida albicans with a MIC value of 8 μg/ml, which is actually even better than the standard drug Amphoptericin B (MIC 10 μg/ml). Conclusion: An expeditious synthesis of several new 3-alkyl-6-(3-aryl-1-phenyl-1H-pyrazol-4-yl)- [1, 2, 4]triazolo[3, 4-b][1, 3, 4]thiadiazoles in 77-89 % yield could be performed from readily accessible starting materials, 5-alkyl-4-amino-3-mercapto-4H-1, 2, 4-triazoles and 3-aryl-1-phenylpyrazole-4- carboxylic acids. Most of the resulting compounds showed moderate to good in vitro activity against Gram-positive bacteria. The title compounds seem to be more active against fungi than bacteria.

Design, Synthesis and Evaluation of Antitubercular Activity of Novel 1,2,4-Triazoles Against MDR Strain of Mycobacterium tuberculosis

Emergence of various forms of resistant strains of Mycobacterium tuberculosis led to the exploration of drugs with novel mechanism of action. Recently econazole, an azole based antitubercular agent, attracted major attention for targeting mycobacterial cytochrome P450. In the present study, we designed novel 1,2,4-triazole derivatives based on econazole moiety and evaluated them for in vitro antitubercular activity against M. tuberculosis H37Rv and multi-drug resistant (MDR) strains of Mycobacterium.