209416-26-2Relevant academic research and scientific papers
Isoquinolinamine and phthalazinamine derivatives: corticotropin-releasing factor receptor CRF1 specific ligands
-
Page column 15, (2010/01/30)
Disclosed are compounds that are highly selective partial agonists or antagonists at human CRF1receptors that are useful in the diagnosis and treatment of treating stress related disorders such as post traumatic stress disorder (PTSD) as well as depression, headache and anxiety. The compounds have the formula or the pharmaceutically acceptable salts thereof wherein Ar, R1, R2, R3, R4and W are various organic and inorganic substituents.
