20945-65-7

Basic information

• Product Name: 2-CHLORO-4-(METHYLSULFONYL)PHENOL
• Synonyms: 2-CHLORO-4-(METHYLSULFONYL)PHENOL
• CAS NO: 20945-65-7
• Molecular Formula: C₇H₇ClO₃S
• Molecular Weight: 206.64668
• Mol File: 20945-65-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 390.371°C at 760 mmHg
• Flash Point: 189.89°C
• Appearance: /
• Density: 1.459g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.571
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-CHLORO-4-(METHYLSULFONYL)PHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-4-(METHYLSULFONYL)PHENOL(20945-65-7)
• EPA Substance Registry System: 2-CHLORO-4-(METHYLSULFONYL)PHENOL(20945-65-7)

Safety Data

• Hazardous Substances Data: 20945-65-7(Hazardous Substances Data)

Usage

General Description

2-Chloro-4-(methylsulfonyl)phenol, also known as CMIT, is a chemical compound with antimicrobial properties that is commonly used in industrial and household products such as disinfectants, water treatment agents, and personal care products. It is effective in controlling the growth of bacteria, fungi, and algae, making it an important ingredient in many products that require preservation or sanitization. However, CMIT has been known to cause skin irritation and allergic reactions in some individuals, leading to ongoing debate about its safety and potential health risks. As a result, regulatory bodies have set limits on its concentration in consumer products and require labeling to inform consumers of its potential hazards.

InChI:InChI=1/C7H7ClO3S/c1-12(10,11)5-2-3-7(9)6(8)4-5/h2-4,9H,1H3

Upstream product

• 38452-47-0 methyl-(3,4-dichlorophenyl)sulphone 
• 98490-92-7 2-chloro-4-methanesulfonyl-1-methoxy-benzene 
• 14763-60-1 4-methanesulfonyl-phenol 
• 792168-92-4 3-chloro-4-methoxy-benzenesulfinic acid 

Downstream Products

• 20951-18-2 C₁₅H₁₄Cl₂O₆S₂ 
• 60963-11-3 1,3-Dichloro-2-(2-chloro-4-methanesulfonyl-phenoxy)-5-nitro-benzene 
• 20951-38-6 2-Bromo-6-chloro-4-methanesulfonyl-phenol 
• 20951-39-7 2-Chloro-6-iodo-4-methanesulfonyl-phenol 
• 20951-15-9 (2-Chloro-4-methanesulfonyl-phenoxy)-acetic acid ethyl ester 
• 36265-30-2 2-Chloro-4-methanesulfonyl-1-(4-nitro-phenoxy)-benzene 
• 60963-39-5 3,5-Dichloro-4-(2-chloro-4-methanesulfonyl-phenoxy)-phenylamine 

Relevant articles and documents

Discovery, structure - Activity relationship, and pharmacological evaluation of (5-substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as potent dipeptidyl peptidase IV inhibitors

A series of (5-substituted pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidine (C5-Pro-Pro) analogues was discovered as dipeptidyl peptidase IV (DPPIV) inhibitors as a potential treatment of diabetes and obesity. X-ray crystallography data show that these inhibitors bind to the catalytic site of DPPIV with the cyano group forming a covalent bond with the serine residue of DPPIV. The C5-substituents make various interactions with the enzyme and affect potency, chemical stability, selectivity, and PK properties of the inhibitors. Optimized analogues are extremely potent with subnanomolar Ki's, are chemically stable, show very little potency decrease in the presence of plasma, and exhibit more than 1,000-fold selectivity against related peptidases. The best compounds also possess good PK and are efficacious in lowering blood glucose in an oral glucose tolerance test in ZDF rats.