20945-65-7

Usage

Uses

Used in Disinfectants:
2-Chloro-4-(methylsulfonyl)phenol is used as an antimicrobial agent in disinfectants for its ability to control the growth of bacteria, fungi, and algae, ensuring the preservation and sanitization of surfaces and objects.
Used in Water Treatment Agents:
In the water treatment industry, 2-Chloro-4-(methylsulfonyl)phenol is used as a biocide to prevent the proliferation of microorganisms that can cause fouling, corrosion, and other issues in water systems.
Used in Personal Care Products:
2-Chloro-4-(methylsulfonyl)phenol is used as a preservative in personal care products such as cosmetics, soaps, and shampoos to maintain their freshness and prevent microbial contamination.
Regulatory Considerations:
Due to the potential for skin irritation and allergic reactions associated with 2-Chloro-4-(methylsulfonyl)phenol, regulatory bodies have established limits on its concentration in consumer products. Additionally, labeling requirements have been put in place to inform consumers of its potential hazards and ensure their safety.

InChI:InChI=1/C7H7ClO3S/c1-12(10,11)5-2-3-7(9)6(8)4-5/h2-4,9H,1H3

Upstream product

• 38452-47-0 methyl-(3,4-dichlorophenyl)sulphone 
• 98490-92-7 2-chloro-4-methanesulfonyl-1-methoxy-benzene 
• 14763-60-1 4-methanesulfonyl-phenol 
• 792168-92-4 3-chloro-4-methoxy-benzenesulfinic acid 

Downstream Products

• 20951-18-2 C₁₅H₁₄Cl₂O₆S₂ 
• 20951-15-9 (2-Chloro-4-methanesulfonyl-phenoxy)-acetic acid ethyl ester 
• 36265-30-2 2-Chloro-4-methanesulfonyl-1-(4-nitro-phenoxy)-benzene 
• 60963-39-5 3,5-Dichloro-4-(2-chloro-4-methanesulfonyl-phenoxy)-phenylamine 
• 20951-39-7 2-Chloro-6-iodo-4-methanesulfonyl-phenol 
• 20951-38-6 2-Bromo-6-chloro-4-methanesulfonyl-phenol 
• 60963-11-3 1,3-Dichloro-2-(2-chloro-4-methanesulfonyl-phenoxy)-5-nitro-benzene 

Relevant academic research and scientific papers

Discovery, structure - Activity relationship, and pharmacological evaluation of (5-substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as potent dipeptidyl peptidase IV inhibitors

A series of (5-substituted pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidine (C5-Pro-Pro) analogues was discovered as dipeptidyl peptidase IV (DPPIV) inhibitors as a potential treatment of diabetes and obesity. X-ray crystallography data show that these inhibitors bind to the catalytic site of DPPIV with the cyano group forming a covalent bond with the serine residue of DPPIV. The C5-substituents make various interactions with the enzyme and affect potency, chemical stability, selectivity, and PK properties of the inhibitors. Optimized analogues are extremely potent with subnanomolar Ki's, are chemically stable, show very little potency decrease in the presence of plasma, and exhibit more than 1,000-fold selectivity against related peptidases. The best compounds also possess good PK and are efficacious in lowering blood glucose in an oral glucose tolerance test in ZDF rats.

PYRROLIDINE-2-CARBONITRILE DERIVATIVES AND THEIR USE AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV)

The present invention relates to compounds of formula (I), (I), which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, syndrome X, hyperinsulinemia, b-cell failure, obesity, satiety disorders, atherosclerosis, and various immunomodulatory diseases.