20948-44-1Relevant articles and documents
Microwave-assisted addition of pyrroles to electron-deficient olefins: A rapid entry to C-alkyl pyrroles
Zhan, Zhuang-Ping,Yang, Wen-Zhen,Yang, Rui-Feng
, p. 2425 - 2428 (2005)
A general procedure for the Michael addition of pyrroles with electron-deficient olefins using silica gel supported reagent under microwave irradiation, has been developed. This new method is fast, efficient, environmentally benign and solvent-free. A cat
Asymmetric Friedel-Crafts alkylation of pyrroles with nitroalkenes using a dinuclear zinc catalyst
Trost, Barry M.,Mueller, Christoph
, p. 2438 - 2439 (2008/09/19)
The catalytic enantioselective and atom economic Friedel-Crafts alkylation of pyrroles with nitroalkenes under mild reaction conditions using a dinuclear zinc catalyst is reported. The versatility of the reaction is demonstrated by the conversion of a number of differentially substituted nitroalkenes with differentially substituted pyrroles. Tandem addition reactions to form 2,5-disubstituted pyrroles are also demsonstrated. All pyrrole alkylations have been carried out without using N-protecting groups, which also enhances the efficiency by which substituted pyrroles may be synthesized. The reactions result in good yields and excellent enantioselectivities. Copyright
Addition of pyrroles to electron deficient olefins employing InCl3
Yadav,Abraham, Sunny,Subba Reddy,Sabitha
, p. 8063 - 8065 (2007/10/03)
Pyrroles undergo conjugate addition with electron deficient olefins in the presence of a catalytic amount of indium trichloride at ambient temperature to afford the corresponding Michael adducts in excellent yields with high selectivity without polymerisa
