209689-22-5Relevant academic research and scientific papers
Metal complexes of biologically important ligands, CIV [1]. Ortho-palladated complexes of N,N-dimethyl-C-phenylglycine-methylester. Synthesis of α-amino acid derivatives by insertion of isocyanides, CO, alkenes, and alkynes into the Pd-C bond
B?hm, Andreas,Polborn, Kurt,Sünkel, Karlheinz,Beck, Wolfgang
, p. 448 - 458 (2007/10/03)
N,N-Dimethyl-C-phenylglycinemethylester reacts with Pd(OAc)2 in acetic acid to give the orthopalladated, acetato bridged complex 1. Treatment of 1 with sodium halide affords the chloro, bromo, and iodo bridged compounds [Me2NC(H)(CO2Me)C6H4PdX]2 (2a - c) (X = halide). From 2a and 1,1′-bis(diphenylphosphino)ferrocene the phosphine bridged trinuclear complex 3 is obtained. Substitution of the amine ligand of 2a by the phosphino group is observed for the reaction of 2a with Ph2PC(Me)C(Me)PPh2. Insertion of 2,6-dimethyl-phenylisocyanide, CO, alkyl-vinyl-ketones, and diphenylacetylene into the Pd-C bond of 2a - c provides the ortho-substituted organic and organometallic derivatives of phenylglycine 6a - c, 7, 8a - b and 9a - c. The crystal structures of 1, 4a, 6a, 7 and 9a were determined by X-ray diffraction.
