20970-65-4

Upstream product

• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 58052-80-5 2,4,6-trimethyl-hexahydro-[1,3,5]triazine; trihydrate 
• 75-07-0 acetaldehyde 

Downstream Products

• 856953-08-7 4-methyl-2,6-diphenyl-pyridine-3,5-dicarbonyl chloride 
• 856955-11-8 4-methyl-2,6-diphenyl-pyridine-3,5-dicarboxylic acid 
• 53531-57-0 4-methyl-2,6-diphenylpyridine 
• 856955-05-0 4-methyl-2,6-diphenyl-pyridine-3,5-dicarboxylic acid diethyl ester 

Relevant academic research and scientific papers

Synthetic Regulation of 1,4-Dihydropyridines for the AIE or AIEE Effect: From Rational Design to Mechanistic Views

Aggregation-induced emission/aggregation-induced emission enhancement (AIE/AIEE) has recently attracted intense research, and a large number of AIE/AIEE luminogens (AIE/AIEEgens) have been constructed for application in diverse scientific fields. The AIE and AIEE effects have similar, but not identical, photophysical behaviors, which are closely related to molecular architectures. However, the current understanding of the inherent differences between AIE and AIEE is still obscure. Herein, a rational design strategy is reported for achieving AIE and AIEE effects by simply incorporating different substituents at the periphery of the same core skeleton. Experimental and theoretical studies on the series of compounds indicated that the restriction of intramolecular twisting motions or/and rotations plays an important role in regard to the corresponding AIE or AIEE behaviors. Moreover, compound 1 a (FW=203, ΦF=80.9 %) was discovered as the lowest molecular weight AIEEgen with a high quantum yield in the solid state despite having no rotatable units. Compound 2 a also exhibited an AIEE effect with the minimum necessary structure (a single ring).

Intermolecular Aryne Ene Reaction of Hantzsch Esters: Stable Covalent Ene Adducts from a 1,4-Dihydropyridine Reaction

The reaction of arynes with 1,4-dihydropyridines affords 2-aryl-1,2-dihydropyridines or 2-methylene-3-aryl-1,2,3,4-tetrahydropyridines via a regioselective C-2 or C-3 arylation. These compounds are the first series of isolable and bench-stable covalent ene adducts formed between dihydropyridines and unsaturated substrates. Experimental studies and DFT calculations provide mechanistic support for a concerted intermolecular aryne ene process, which may have implications for NAD(P)H model reactions.