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LOXO-195 is a chemical compound that serves as a targeted therapy for cancer, acting as an inhibitor of the tropomyosin receptor kinase (TRK) family of proteins. These proteins are implicated in the growth and spread of cancer cells, and by inhibiting them, LOXO-195 may halt the abnormal cell growth and division characteristic of cancer. Early research has demonstrated its potential in treating certain cancers, and it is currently under clinical trials to assess its safety and efficacy.

2097002-61-2

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  • (3aR,10R)-5-Fluoro-1,2,3,3a,8,9,10,11-octahydro-10-methyl-12H-15,17-ethenopyrazolo[3,4-d]pyrido[2,3-k]pyrrolo[2,1-m][1,3,7]triazacyclotridecin-12-one

    Cas No: 2097002-61-2

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2097002-61-2 Usage

Uses

Used in Oncology:
LOXO-195 is used as a targeted cancer therapy for its ability to inhibit the TRK family of proteins, which are involved in the growth and spread of cancer cells. This application is particularly relevant for treating certain types of solid tumors and sarcomas, where the compound has shown promising results in early studies.
Used in Pharmaceutical Development:
In the pharmaceutical industry, LOXO-195 is utilized in the development of new cancer treatments. Its role as a TRK inhibitor positions it as a candidate for further research and clinical trials aimed at establishing its safety and effectiveness in treating cancer patients.
Used in Clinical Trials:
LOXO-195 is used in clinical trials to evaluate its safety, tolerability, and effectiveness as a cancer treatment. These trials are essential for determining the appropriate dosing, potential side effects, and overall therapeutic value of the compound in treating specific types of cancer.

Check Digit Verification of cas no

The CAS Registry Mumber 2097002-61-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 2,0,9,7,0,0 and 2 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 2097002-61:
(9*2)+(8*0)+(7*9)+(6*7)+(5*0)+(4*0)+(3*2)+(2*6)+(1*1)=142
142 % 10 = 2
So 2097002-61-2 is a valid CAS Registry Number.

2097002-61-2Downstream Products

2097002-61-2Relevant articles and documents

FORMULATIONS OF A MACROCYCLIC TRK KINASE INHIBITOR

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, (2019/05/15)

The present application in some embodiments provides a pharmaceutical composition comprising Compound (1), and a compounding agent. Further provided herein are methods of making and methods of using the pharmaceutical compositions, for example, in the treatment of cancer.

PROCESS FOR THE PREPARATION OF PYRAZOLO[1,5-a]PYRIMIDINES AND SALTS THEREOF

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, (2018/05/24)

In some embodiments, provided herein are processes for preparing a compound of Formula C or a salt thereof, as disclosed herein. In some embodiments, provided herein is a compound of Formula I or a pharmaceutically acceptable salt, solvate or hydrate thereof. In some embodiments, provided herein is a solid form of the compound, such as a crystalline form of the compound crystalline Form I.

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