1213093-30-1 Usage
Description
(R)-5-fluoro-2-methoxy-3-(pyrrolidin-2-yl)pyridine is a chemical compound with a specific molecular structure that features a pyridine ring, a fluorine atom, a methoxy group, and a pyrrolidinyl group. (R)-5-fluoro-2-methoxy-3-(pyrrolidin-2-yl)pyridine has been identified for its potential applications in various fields, particularly as a selective Trk kinase inhibitor.
Uses
Used in Pharmaceutical Industry:
(R)-5-fluoro-2-methoxy-3-(pyrrolidin-2-yl)pyridine is used as a selective Trk kinase inhibitor for its potential role in the development of targeted therapies for various diseases. Trk kinases are a family of receptor tyrosine kinases that play a crucial role in cell growth, survival, and differentiation. Inhibition of these kinases can be beneficial in treating conditions where uncontrolled cell growth or survival is a concern, such as cancer.
The compound's selectivity for Trk kinases makes it a promising candidate for the development of drugs with fewer off-target effects, which can lead to improved safety and efficacy profiles. Further research and development are necessary to fully understand the potential applications and limitations of (R)-5-fluoro-2-methoxy-3-(pyrrolidin-2-yl)pyridine in the pharmaceutical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 1213093-30-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,1,3,0,9 and 3 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1213093-30:
(9*1)+(8*2)+(7*1)+(6*3)+(5*0)+(4*9)+(3*3)+(2*3)+(1*0)=101
101 % 10 = 1
So 1213093-30-1 is a valid CAS Registry Number.
1213093-30-1Relevant articles and documents
Macrocyclic compound, and preparation method and application thereof
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, (2021/06/23)
The invention discloses a macrocyclic kinase inhibitor, and a compound, or a stereoisomer or a pharmaceutically acceptable salt thereof as shown in a formula (I). Experiments show that the novel compound shown in the formula (I) shows good TRK inhibitory
Pyrazolopyrimidine macrocyclic derivative and application thereof
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Paragraph 0046; 0051, (2020/11/26)
The invention relates to a novel pyrazolopyrimidine macrocyclic derivative as well as a preparation method and application thereof in medicines. Specifically, the invention relates to a new pyrazolopyrimidine macrocyclic derivative as shown in a general formula (I), a preparation method thereof, and application of the pyrazolopyrimidine macrocyclic derivative or a pharmaceutical composition containing the derivative as a therapeutic agent, especially as a tropomyosin-related kinase (TRK) inhibitor, in treatment or prevention of TRK-mediated related diseases such as tumors. Substituents (R1, R2) and groups (X) in the general formula (I) are as defined in the description.
FORMULATIONS OF A MACROCYCLIC TRK KINASE INHIBITOR
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Page/Page column 204; 205, (2019/05/15)
The present application in some embodiments provides a pharmaceutical composition comprising Compound (1), and a compounding agent. Further provided herein are methods of making and methods of using the pharmaceutical compositions, for example, in the treatment of cancer.
