20973-68-6

Upstream product

• 5815-08-7 tert-Butoxybis(dimethylamino)methane 
• 99-99-0 1-methyl-4-nitrobenzene 
• 20353-93-9 Gold's reagent 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 1460-05-5 p-nitrophenylacetaldehyde 
• 81321-43-9 1-[5-Dimethylamino-1-(4-fluoro-phenyl)-4-(4-nitro-phenyl)-4,5-dihydro-1H-pyrazol-3-yl]-ethanone 
• 81321-67-7 3-Bromomethyl-1,4-bis-(4-fluoro-phenyl)-1H-pyrazole 
• 81321-58-6 [1,4-Bis-(4-fluoro-phenyl)-1H-pyrazol-3-yl]-methanol 
• 81321-75-7 [1,4-Bis-(4-fluoro-phenyl)-1H-pyrazol-3-yl]-acetonitrile 
• 81321-46-2 1,4-Bis(4-fluorphenyl)-pyrazol-3-carbonsaeure-ethylester 
• 72603-01-1 4-(4-Aminophenyl)-1-(4-fluorphenyl)pyrazol-3-carbonsaeure-ethylester 
• 77443-10-8 [1,4-Bis-(4-fluoro-phenyl)-1H-pyrazol-3-yl]-acetic acid 
• 81321-63-3 [1-(4-Fluoro-phenyl)-4-(4-nitro-phenyl)-1H-pyrazol-3-yl]-methanol 
• 81321-72-4 3-Bromomethyl-1-(4-fluoro-phenyl)-4-(4-nitro-phenyl)-1H-pyrazole 
• 81321-80-4 [1-(4-Fluoro-phenyl)-4-(4-nitro-phenyl)-1H-pyrazol-3-yl]-acetonitrile 
• 77443-13-1 [1-(4-Fluoro-phenyl)-4-(4-nitro-phenyl)-1H-pyrazol-3-yl]-acetic acid 
• 81321-51-9 1-(4-Fluorphenyl)-4-(4-nitrophenyl)-pyrazol-3-carbonsaeure-ethylester 
• 64989-96-4 4-(4-Methoxyphenyl)-1-phenyl-pyrazol-3-carbonsaeure-ethylester 

Relevant academic research and scientific papers

HCV NS5A replication complex inhibitors. Part 3

In a recent disclosure,1 we described the discovery of dimeric, prolinamide-based NS5A replication complex inhibitors exhibiting excellent potency towards an HCV genotype 1b replicon. That disclosure dealt with the SAR exploration of the peripheral region of our lead chemotype, and herein is described the SAR uncovered from a complementary effort that focused on the central core region. From this effort, the contribution of the core region to the overall topology of the pharmacophore, primarily vector orientation and planarity, was determined, with a set of analogs exhibiting 50 in a genotype 1b replicon assay.

Facile, environmentally friendly synthesis of benzaldehyde and phenylacetaldehyde analogs from readily available toluene derivatives

A facile environmentally friendly synthesis of bezaldehyde and phenylacetaldehyde analogs from readily available toluene derivatives is described. Oxidation of the styrylamines by H2O2 H2O2 affords benzaldehydes in moderate yields, while the hydrolysis of styrylamines afforded phenylacetaldehyde analogs in good yields. Copyright

REACTION OF GOLD'S REAGENT WITH ACTIVATED METHYLENE GROUPS DERIVED FROM ESTERS AND NITROARENES

A series of esters and nitrotoluenes were reacted with Gold's reagent under basic conditions and were found to produce the corresponding dimethylamino methyleneated product in both cases.