209798-73-2

Upstream product

• 769-42-6 1,3-dimethylbarbituric acid 
• 209798-65-2 7,7-bis(dimethylamino)-6,6-difluoro-1,3-dimethyl-5-(4'-fluorophenyl)-1,3,4,5,6,7-hexahydro-2H-pyrano[2,3-d]pyrimidine-2,4-dione 
• 114702-43-1 5-(4-fluorobenzylidene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione 
• 459-57-4 4-fluorobenzaldehyde 
• 209798-69-6 N,N-dimethyl-3-(1,3-dimethyl-2,4,6-trioxohexahydro-5-pyrimidinyl)-2,2-difluoro-3-(4-fluorophenyl)propanamide 

Relevant academic research and scientific papers

Synthesis of novel fluorinated derivatives of 1,3-dimethylbarbituric acid

Synthetic utility of the novel difluoro ketene aminal 1 was extended to the preparation of a number of potentially biologically-interesting difluoro barbituric acid derivatives via initial hetero-Diels-Alder reactions of 1 with p-substituted-5-benzylidene-1,3-dimethylbarbituric acids 3. These cycloadducts 4 upon hydrolysis, provided the formal Michael addition product amides 5 which were readily converted to the respective carboxylic acids 6. The acids were dehydratively cyclized to form novel bicyclic lactones 8.