2098457-92-0

Basic information

• Product Name: 1-(4-Methoxyphenyl)-6-(4-(2-Methyl-6-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide
• Synonyms: 1-(4-Methoxyphenyl)-6-(4-(2-Methyl-6-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide
• CAS NO: 2098457-92-0
• Molecular Formula: C26H27N5O4
• Molecular Weight: 473.52368
• EINECS: -0
• Mol File: 2098457-92-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 766.0±60.0 °C(Predicted)
• Appearance: /
• Density: 1.39±0.1 g/cm3(Predicted)
• PKA: 15.01±0.20(Predicted)
• CAS DataBase Reference: 1-(4-Methoxyphenyl)-6-(4-(2-Methyl-6-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Methoxyphenyl)-6-(4-(2-Methyl-6-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide(2098457-92-0)
• EPA Substance Registry System: 1-(4-Methoxyphenyl)-6-(4-(2-Methyl-6-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide(2098457-92-0)

Safety Data

• Hazardous Substances Data: 2098457-92-0(Hazardous Substances Data)

Usage

Uses

1-?(4-?Methoxyphenyl)?-?6-?(4-?(2-?methyl-?6-?oxopiperidin-?1-?yl)?phenyl)?-?7-?oxo-?4,?5,?6,?7-?tetrahydro-?1H-?pyrazolo[3,?4-?c]?pyridine-?3-?carboxamide is an impurity of Apixaban (A726700), A potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.

Upstream product

• 3128-06-1 5-ketohexanoic acid 
• 1267610-26-3 1-(4-aminophenyl)-3-(morpholin-4-yl)-5,6-dihydropyridin-2(1H)-one 
• 13984-57-1 ethyl 5-oxohexanoate 
• 4775-98-8 δ-caprolactam 
• 473927-69-4 1-(4-iodo-phenyl)-3-morpholin-4-yl-5,6-dihydro-1H-pyridin-2-one 

Relevant articles and documents

Preparation method of apixaban impurity 1

The invention provides a preparation method of an apixaban impurity 1, and relates to the technical field of drug impurity synthesis. The method comprises the following steps: by taking a compound 1-(4-aminophenyl)-5, 6-dihydro-3-(4-morpholinyl)-2-(1H)-pyridone as an initial raw material, carrying out amination reduction acid amine condensation, cyclization-elimination and amine ester exchange three-step reaction to obtain the apixaban impurity 1; according to the method, the reaction raw materials are simple and easy to obtain, the reaction conditions and experimental operation are simple, harsh conditions, expensive reagents, equipment and the like are not needed, meanwhile, the reaction conditions are mild, the process is simple, the reaction time is short, the yield is good, and the apixaban impurity 1 with higher reaction yield and very high impurity purity can be obtained. The invention provides a reliable impurity reference substance for quality control research of apixaban, andhas great significance.

Apixaban related substance, intermediate, preparation method and applications thereof

The present invention discloses an apixaban related substance, an intermediate, a preparation method and applications thereof. The present invention provides an apixaban related substance I and a preparation method thereof, wherein the preparation method comprises that in an organic solvent, in the presence of sodium methoxide, a compound II and formamide are subjected to an amidation reaction so as to obtain the apixaban related substance I. According to the present invention, the yield of the synthesis method is high, and the subsequent quality control research in the apixaban preparation process is conveniently performed. The formulas I and II are defined in the specification.