473927-69-4

Basic information

• Product Name: 1-(4-iodophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one
• Synonyms: 1-(4-iodophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one;N-(4-Iodophenyl)-3-morpholino-5,6-dihydro-2H-pyridin-2-one;Apixaban III;1-(4-iodo-phenyl)-3-Morpholin-4-yl-5,6-dihydro-1H-pyridin-2-one;5,6-dihydro-1-(4-iodophenyl)-3-(4-morpholinyl)-2(1H)-Pyridinone;1-(4-Iodophenyl);-3-morpholino-5,6-dihydropyridin-2(1H)
• CAS NO: 473927-69-4
• Molecular Formula: C₁₅H₁₇IN₂O₂
• Molecular Weight: 384.21215
• EINECS: 1308068-626-2
• Mol File: 473927-69-4.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 483.485 °C at 760 mmHg
• Flash Point: 246.203 °C
• Appearance: /
• Density: 1.643
• Storage Temp.: 2-8°C(protect from light)
• PKA: 3.23±0.20(Predicted)
• CAS DataBase Reference: 1-(4-iodophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-iodophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one(473927-69-4)
• EPA Substance Registry System: 1-(4-iodophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one(473927-69-4)

Safety Data

• Hazardous Substances Data: 473927-69-4(Hazardous Substances Data)

Usage

General Description

1-(4-Iodophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one is a chemical compound with potential pharmacological properties. It is a dihydropyridinone derivative with an iodophenyl group and a morpholine ring. 1-(4-Iodophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one has been studied for its potential as a calcium channel blocker, which could make it useful in the treatment of cardiovascular diseases such as hypertension and angina. Additionally, it has shown potential as an anti-neoplastic agent, with studies indicating its ability to inhibit the growth of cancer cells. 1-(4-Iodophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one's unique structure and potential pharmacological activities make it of interest for further research and development in the field of medicinal chemistry.

Upstream product

• 110-91-8 morpholine 
• 385425-15-0 1-(2-oxopiperidin-1-yl)-4-iodobenzene 
• 545445-10-1 3,3-dichloro-1-(4-iodophenyl)-piperidin-2-one 
• 2067-33-6 5-bromopentanoic acid 
• 540-37-4 p-aminoiodobenzene 
• 4509-90-4 5-bromovaleroyl chloride 

Downstream Products

• 385425-14-9 1-(4-iodophenyl)-4-(2,2,2-trifluoroacetyl)-piperidine-2,3-dione 
• 473927-67-2 6-(4-iodophenyl)-1-(4-methoxyphenyl)-3-(methylsulfonyl)-1,4,5,6-tetrahydro-7H-pyrazolo(3,4-c)pyridin-7-one 
• 473927-64-9 1-(4-methoxy-phenyl)-6-(4-iodo-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester 
• 543745-11-5 1-(3-cyano-4-fluoro)phenyl-3-trifluoromethyl-6-(4-iodo)phenyl-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one 
• 543745-12-6 1-(3-Cyano-4-fluoro)phenyl-3-trifluoromethyl-6-[4-(2-formyl)phenyl]phenyl-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF APIXABAN

The present invention relates to an improved process for the preparation of Apixaban and its intermediates.

LACTAM-CONTAINING COMPOUNDS AND DERIVATIVES THEREOF AS FACTOR XA INHIBITORS

The present application describes lactam-containing compounds and derivatives thereof of Formula I: P4—P-M-M4??I or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7 membered carbocycle or heterocycle and ring M is a 5-7 membered carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.

NOVEL PROCESS FOR THE PREPARATION OF A LACTAM-CONTAINING COMPOUND

Provided herein is a novel, commercially viable and industrially advantageous process for the preparation of 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazole-[3,4-c]pyridine-3-carboxamide, in high yield and with high purity, using a novel intermediate 3-chloro-1-(4-iodophenyl)-5,6-dihydropyridin-2(1H)-one.