209850-63-5

Upstream product

• 1161431-54-4 N-[(2S)-4-methoxy-1-phenylhexa-4,5-dien-2-yl]-4-methylbenzene-1-sulfonamide 
• 90365-18-7 N-(p-toluenesulfonyl)-L-phenylalanyl chloride 
• 13505-32-3 N-tosyl-(S)-phenylalanine 
• 10119-00-3 tosyl-L-phenylalanyl diazomethane 
• 67-56-1 methanol 

Downstream Products

• 172534-72-4 (3S)-(p-toluenesulfonyl)amino-4-phenylbutyric acid 
• 209850-57-7 N-((S)-1-Benzyl-4-diazo-3-oxo-butyl)-4-methyl-benzenesulfonamide 
• 221468-44-6 (S)-4-phenyl-3-tosylamidobutanoyl chloride 

Relevant academic research and scientific papers

Addition of lithiated methoxyallene to aziridines - A novel access to enantiopure piperidine and β-amino acid derivatives

Addition of lithiated methoxyallene to aziridine derivatives provided the expected primary addition products. The less substituted carbon of the aziridine ring was attacked selectively. The primary adducts could be converted to enantiopure piperidine deri

Wolff rearrangement of diazo ketones derived from N-p-tolylsulfonyl-protected α- and β-amino acids

Diazo ketones derived from N-p-tolylsulfonyl (tosyl)-protected α- and β-amino acids have been synthesized and their diazo decomposition under standard Wolff rearrangement conditions, PhCO2Ag-Et3N-MeOH, has been investigated. It is observed that, under these conditions, several different reaction pathways, including direct carbene N-H insertion, are possible. The reaction is markedly affected by the N-protecting group, the substrate structure and solvent. For those diazo ketones derived from N-tosyl-protected β-amino acids, the diazo decomposition with anhydrous THF as solvent and PhCO2Ag dissolved in Et3N as catalyst gives the corresponding 5-substituted pyrrolidinones in excellent yields.