2098543-62-3

Usage

Uses

Used in Organic Synthesis:
2H-Pyran, 4-[(1R)-2-bromo-1-(2-methoxyphenyl)ethoxy]tetrahydrois used as a building block in organic synthesis for constructing more complex molecules. Its unique structure allows for the creation of a wide range of chemical compounds with diverse properties and applications.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2H-Pyran, 4-[(1R)-2-bromo-1-(2-methoxyphenyl)ethoxy]tetrahydrois utilized as a reagent in the preparation of various pharmaceutical compounds and biologically active substances. Its presence in the synthesis process can contribute to the development of new drugs with improved efficacy and selectivity.
Used in Drug Discovery and Development:
The presence of bromine and methoxy groups in the structure of 2H-Pyran, 4-[(1R)-2-bromo-1-(2-methoxyphenyl)ethoxy]tetrahydroprovides it with potentially useful properties for drug discovery and development. These functional groups can be further modified or used as starting points for the design of new drug candidates with specific therapeutic targets.
Overall, 2H-Pyran, 4-[(1R)-2-bromo-1-(2-methoxyphenyl)ethoxy]tetrahydrohas a variety of applications in the fields of chemistry and pharmaceutical research, making it a valuable compound for the synthesis of complex molecules and the development of novel pharmaceutical agents.

Upstream product

• 1434652-62-6 2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethan-1-ol 
• 62717-78-6 2-(2-methoxyphenyl)oxirane 
• 2081-44-9 Tetrahydro-pyran-4-ol 
• 93-25-4 2-methoxyphenylacetic acid 
• 1434652-66-0 (R)-2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethan-1-ol 
• 135-02-4 ortho-anisaldehyde 

Downstream Products

• 1434635-54-7 1,4-dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl- 6-(2-oxazolyl)-2,4-dioxo-thieno[2,3-d]pyrimidine-3(2H)-acetic acid 

Relevant academic research and scientific papers

ACC inhibitor and application thereof

The invention provides a compound suitable for being used as an acetyl CoA carboxylase (ACC) inhibitor, in particular a thienopyridine derivative, and application of the compound in preparation of medicines for treating metabolic diseases, cancers or other proliferative diseases.

Optical isomer of ACC inhibitor and application thereof

The invention belongs to the field of medical chemistry. The invention relates to an optical isomer of an ACC inhibitor and application of the optical isomer. Specifically, the invention provides optical isomers shown as a formula I or a formula II (See the specification for reference) or hydrates, solvates, crystals or pharmaceutically acceptable salts thereof, preparation methods thereof, pharmaceutical compositions containing the optical isomers or hydrates, solvates, crystals or pharmaceutically acceptable salts thereof, and applications of the optical isomers or hydrates, solvates, crystals or pharmaceutically acceptable salts thereof in treating tumors. The compound provided by the invention has good inhibitory activity on ACC, and is very hopeful to become a therapeutic agent with higher curative effect and smaller side effects for ACC expression related diseases, such as fibrotic diseases, metabolic diseases, cancers or tissue hyperplasia diseases.

COMPOUND AS ACC INHIBITOR AND USE THEREOF

Disclosed are a class of compounds which are inhibitors of acetyl-CoA carboxylase (ACC) and the use thereof. In particular, provided are compounds as shown in formula I or isomers, pharmaceutically acceptable salts, solvates, crystals or prodrugs thereof, and methods for preparing the same, and pharmaceutical compositions comprising the compounds and the use of the compounds or compositions for treating and/or preventing diseases associated with ACC expression, such as fibrotic diseases, metabolic diseases, cancers or tissue hyperplasia diseases. The compound has a good inhibitory activity against ACC and shows good promise to be a therapeutic drug for fibrotic diseases, metabolic diseases, cancers or tissue hyperplasia diseases.

Preparation method of thienopyrimidinedione compound

The invention provides a preparation method of a compound shown as a general formula c, wherein the definition of substituent is as defined in the specification. Please see the specification for the formula.

Preparation method of ACC inhibitor and intermediate thereof

The invention relates to the technical field of organic compound synthesis, in particular to a . The preparation method of the intermediate of the ACC inhibitor comprises the following steps: a, performing a halogenation reaction on a compound I to obtain

SOLID FORMS OF A THIENOPYRIMIDINEDIONE ACC INHIBITOR AND METHODS FOR PRODUCTION THEREOF

The present invention provides solid forms of compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, methods of producing the same, and methods of using the same in the treatment of ACC-mediated diseases.

ESTER ACC INHIBITORS AND USES THEREOF

The present invention provides ester compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.