209901-49-5Relevant academic research and scientific papers
Design, synthesis and biological evaluation of pentacyclic triterpene derivatives: Optimization of anti-Abl kinase activity
Ciftci, Halil I.,Radwan, Mohamed O.,Ozturk, Safiye E.,Gokce Ulusoy,Sozer, Ece,Ellakwa, Doha E.,Ocak, Zeynep,Can, Mustafa,Ali, Taha F.S.,Abd-Alla, Howaida I.,Yayli, Nurettin,Tateishi, Hiroshi,Otsuka, Masami,Fujita, Mikako
, (2019)
Imatinib, an Abelson (ABL) tyrosine kinase inhibitor, is a lead molecular-targeted drug against chronic myelogenous leukemia (CML). To overcome its resistance and adverse effects, new inhibitors of ABL kinase are needed. Our previous study showed that the
Synthesis and biological evaluation of asiatic acid derivatives as inhibitors of glycogen phosphorylases
Zhang, Liying,Chen, Jun,Gong, Yanchun,Liu, Jun,Zhang, Luyong,Hua, Weiyi,Sun, Hongbin
experimental part, p. 864 - 874 (2010/04/23)
Twenty-four asiatic acid derivatives have been synthesized and biologically evaluated as inhibitors of glycogen phosphorylase (GP). Within this series of compounds, asiatic acid benzyl ester (23; IC50=3.8 μm) exhibited more potent activity than
