209909-13-7

Basic information

• Product Name: 2-Chloro-6,7-difluoro-3-quinolinecarboxaldehyde
• Synonyms: 2-CHLORO-6,7-DIFLUORO-3-QUINOLINE CARBOXALDEHYDE;2-Chloro-6,7-difluoroquinoline-3-carbaldehyde
• CAS NO: 209909-13-7
• Molecular Formula: C₁₀H₄ClF₂NO
• Molecular Weight: 227.59
• Mol File: 209909-13-7.mol

Chemical Properties

• Boiling Point: 344.847°C at 760 mmHg
• Flash Point: 162.358°C
• Appearance: /
• Density: 1.529
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.643
• Storage Temp.: 2-8°C
• PKA: -3.16±0.50(Predicted)
• CAS DataBase Reference: 2-Chloro-6,7-difluoro-3-quinolinecarboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-6,7-difluoro-3-quinolinecarboxaldehyde(209909-13-7)
• EPA Substance Registry System: 2-Chloro-6,7-difluoro-3-quinolinecarboxaldehyde(209909-13-7)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 209909-13-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
2-Chloro-6,7-difluoro-3-quinolinecarboxaldehyde is used as a key intermediate in the synthesis of pharmaceuticals, contributing to the development of new drugs due to its unique chemical structure and reactivity.
Used in Agrochemical Production:
In the agrochemical industry, 2-Chloro-6,7-difluoro-3-quinolinecarboxaldehyde is employed as a precursor in the creation of various agrochemicals, potentially enhancing crop protection and yield.
Used in Dye Manufacturing:
2-Chloro-6,7-difluoro-3-quinolinecarboxaldehyde also finds application in the dye industry, where it is used in the synthesis of dyes, adding to the color palette available for various industrial applications.
Safety Considerations:
2-Chloro-6,7-difluoro-3-quinolinecarboxaldehyde is considered harmful if ingested, inhaled, or absorbed through the skin, and it may cause respiratory and skin irritation. Therefore, it necessitates careful handling and storage with appropriate safety measures to mitigate potential health risks.

InChI:InChI=1/C10H4ClF2NO/c11-10-6(4-15)1-5-2-7(12)8(13)3-9(5)14-10/h1-4H

Upstream product

• 458-11-7 3,4-difluoroacetanilide 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 186668-70-2 5-ethyl-9,10-difluoro-5-hydroxy-1,4,5,13-tetrahydro-3H,15H-oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione 

Relevant articles and documents

BICYCLIC DERIVATIVES AS CETP INHIBITORS

The present invention relates to novel compounds of formula (I): or a pharmaceutical composition thereof, with all the variables being defined in the text. The present invention further relates to the use of the compounds herein for treatment of or delay

Analogues of camptothecin, their use as medicaments and the pharmaceutical compositions containing them

A compound of the formula wherein the substituents are defined as in the specification which compounds are useful in the treatment of cancer.

New analogues of camptothecin, their use as medicaments and the pharmaceutical compositions containing them

A compound of the formula wherein the substituents are defined as in the specification which compounds are useful in the treatment of cancer.

Comptothecin analogues, preparation methods therefor, use thereof as drugs, and pharmaceutical compositions containing said analogues

The compound of the formula wherein the substituents are defined as in the specification and its non-toxic, pharmaceutically acceptable salts which are useful for the treatment of viral infections, parasitic diseases and the treatment of cancer.

Homocamptothecins: Synthesis and antitumor activity of novel E-ring- modified camptothecin analogues

Homocamptothecin (hCPT), a camptothecin (CPT) analogue with a seven membered β-hydroxylactone which combines enhanced plasma stability and potent topoisomerase I (Topo I) mediated activity, is an attractive template for the elaboration of new anticancer a