186668-70-2 Usage
General Description
Diflomotecan is a synthetic derivative of the quinoline alkaloid camptothecin, which exhibits potent anticancer activity by inhibiting the enzyme topoisomerase I. This inhibition leads to the accumulation of DNA damage and ultimately induces cell death in cancer cells. Diflomotecan has shown promise in preclinical and clinical studies for the treatment of various solid tumors, including lung, breast, and ovarian cancers. Its unique chemical structure and mechanism of action make it a promising candidate for further development as a potential therapy for cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 186668-70-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,6,6,6 and 8 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 186668-70:
(8*1)+(7*8)+(6*6)+(5*6)+(4*6)+(3*8)+(2*7)+(1*0)=192
192 % 10 = 2
So 186668-70-2 is a valid CAS Registry Number.
186668-70-2Relevant articles and documents
Analogues of camptothecin, their use as medicaments and the pharmaceutical compositions containing them
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, (2008/06/13)
A compound of the formula wherein the substituents are defined as in the specification which compounds are useful in the treatment of cancer.
Comptothecin analogues, preparation methods therefor, use thereof as drugs, and pharmaceutical compositions containing said analogues
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Example 18, (2008/06/13)
The compound of the formula wherein the substituents are defined as in the specification and its non-toxic, pharmaceutically acceptable salts which are useful for the treatment of viral infections, parasitic diseases and the treatment of cancer.
