186668-70-2

Usage

Uses

Used in Oncology:
Diflomotecan is used as an anticancer agent for the treatment of various solid tumors, including lung, breast, and ovarian cancers. Its mechanism of action involves the inhibition of topoisomerase I, leading to the accumulation of DNA damage and inducing cell death in cancer cells.
Used in Pharmaceutical Industry:
Diflomotecan is used as a potential therapy for cancer due to its unique chemical structure and mechanism of action. Its development as a pharmaceutical agent is ongoing, with the aim of improving treatment options for patients with various solid tumors.

Upstream product

• 209909-04-6 8-<(2-chloro-6,7-difluoro-3-quinolyl)methyl>-5-ethyl-1,4,5,8tetrahydro-5-hydroxyoxepino<3,4-c>pyridine-3,9-dione 
• 87121-53-7 1-(2-chloropyridin-4-yl)propan-1-one 
• 219832-71-0 4-(2-ethyl[1,3]dioxolan-2-yl)-2-methoxypyridine 
• 209909-13-7 2-chloro-6,7-difluoro-3-quinoline-3-carbaldehyde 
• 880767-51-1 4-(2-ethyl[1,3]dioxolan-2-yl)-2-methoxypyridine-3-carbaldehyde 
• 186668-54-2 (+)-5-ethyl-5-hydroxy-1,3,4,5,8,9-hexahydrooxepino[3,4-c]pyridin-3,9-dione 
• 209909-03-5 2-chloro-6,7-difluoro-3-quinolinemethanol 
• 186668-53-1 (+)-(5R)-5-Ethyl-5-hydroxy-1-methoxy-5.6-dihydro-9H-8-oxa-2-aza-benzocyclohepten-7-one 
• 219832-72-1 4(2-ethyl-1,3-dioxan-2-yl)-3-hydroxymethyl-2-methyoxypyridine 
• 186668-50-8 1-{3-[(benzyloxy)methyl]-2-methoxy-4-pyridinyl}-1-propanone 
• 186668-52-0 tert-butyl 3-hydroxy-3-[3-(hydroxymethyl)-2-methoxy-4-pyridinyl]pentanoate 
• 880767-52-2 3-benzyloxymethyl-4-(2-ethyl[1,3]dioxolan-2-yl)-2-methoxypyridine 
• 186668-51-9 tert-butyl 3-{3-[(benzyloxy)methyl]-2-methoxy-4-pyridinyl}-3-hydroxypentanoate 
• 68-12-2 N,N-dimethyl-formamide 

Relevant academic research and scientific papers

Analogues of camptothecin, their use as medicaments and the pharmaceutical compositions containing them

A compound of the formula wherein the substituents are defined as in the specification which compounds are useful in the treatment of cancer.

New analogues of camptothecin, their use as medicaments and the pharmaceutical compositions containing them

A compound of the formula wherein the substituents are defined as in the specification which compounds are useful in the treatment of cancer.

Comptothecin analogues, preparation methods therefor, use thereof as drugs, and pharmaceutical compositions containing said analogues

The compound of the formula wherein the substituents are defined as in the specification and its non-toxic, pharmaceutically acceptable salts which are useful for the treatment of viral infections, parasitic diseases and the treatment of cancer.

Homocamptothecins: Synthesis and antitumor activity of novel E-ring- modified camptothecin analogues

Homocamptothecin (hCPT), a camptothecin (CPT) analogue with a seven membered β-hydroxylactone which combines enhanced plasma stability and potent topoisomerase I (Topo I) mediated activity, is an attractive template for the elaboration of new anticancer a