209910-33-8

Basic information

• Product Name: L-Proline, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-(phenylmethyl)-L-tyrosyl-, methyl ester
• CAS NO: 209910-33-8
• Molecular Formula: C37H36N2O6
• Molecular Weight: 604.703
• Mol File: 209910-33-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: L-Proline, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-(phenylmethyl)-L-tyrosyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Proline, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-(phenylmethyl)-L-tyrosyl-, methyl ester(209910-33-8)
• EPA Substance Registry System: L-Proline, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-(phenylmethyl)-L-tyrosyl-, methyl ester(209910-33-8)

Safety Data

• Hazardous Substances Data: 209910-33-8(Hazardous Substances Data)

Upstream product

• 2577-48-2 methyl (2S)-pyrrolidine carboxylate 
• 103321-60-4 Fmoc-Tyr(OBn)-Cl 
• 2133-40-6 L-proline methyl ester monohydrochloride 

Downstream Products

• 221174-22-7 Fmoc-Tyr(Bzl)-Pro-Phe-Pro-Gly-OBzl 
• 209910-43-0 Fmoc-Tyr(Bzl)-Pro-Phe-OMe 
• 209910-44-1 Fmoc-Tyr(Bzl)-Pro-Phe-OH 
• 209910-42-9 Fmoc-Tyr(Bzl)-Pro-Phe-Cl 
• 209910-32-7 Fmoc-Tyr(Bzl)-Pro-Cl 
• 72122-63-5 bovine β-casomorphin-5 
• 209910-34-9 Fmoc-Tyr(OBn)-Pro-OH 

Relevant articles and documents

HOAt.DCHA as co-coupling agent in the synthesis of peptides employing Fmoc-amino acid chlorides as coupling agents: Application to the synthesis of ss-casomorphin

A simple, efficient and racemization free method for the synthesis of peptides employing Fmoc-amino acid chlorides mediated by HOAtDCHA as a co-coupling agent has been described. This protocol is successfully employed in the synthesis of the pentapeptide H-Pro-Gly-VaI-GIy-VaI-OH (PGVGV), and ss-casomorphin (H-Tyr-Pro-Phe-Pro-Gly-OH) in 85 and 80% yields, respectively.

Fmoc-peptide acid chlorides : Preparation, characterization and utility in peptide synthesis

Fmoc-protected peptide acid chlorides have been prepared as crystalline solids and characterized They are used as coupling agents for the synthesis of the model tetrapeptide, Leu-Ala-Gly-Val.