209917-92-0

Basic information

• Product Name: 2'-TRIFLUOROMETHYL-BIPHENYL-4-YLAMINE
• Synonyms: AKOS BH-0178;2'-TRIFLUOROMETHYL-BIPHENYL-4-YLAMINE;2'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-4-AMINE;2'-(Trifluoromethyl)-biphenyl-4-amine
• CAS NO: 209917-92-0
• Molecular Formula: C₁₃H₁₀F₃N
• Molecular Weight: 237.22
• Mol File: 209917-92-0.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2'-TRIFLUOROMETHYL-BIPHENYL-4-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-TRIFLUOROMETHYL-BIPHENYL-4-YLAMINE(209917-92-0)
• EPA Substance Registry System: 2'-TRIFLUOROMETHYL-BIPHENYL-4-YLAMINE(209917-92-0)

Safety Data

• Hazardous Substances Data: 209917-92-0(Hazardous Substances Data)

Usage

General Description

2'-Trifluoromethyl-biphenyl-4-ylamine is a chemical compound with the molecular formula C13H10F3N. It is a member of the amine family, and its structure contains a biphenyl group with a trifluoromethyl group attached to the 2' position. 2'-TRIFLUOROMETHYL-BIPHENYL-4-YLAMINE is used in organic synthesis and has potential applications in the pharmaceutical and agrochemical industries. It may also be used as a building block for the synthesis of other organic compounds. Depending on its specific use, 2'-trifluoromethyl-biphenyl-4-ylamine may have different properties and reactivity.

Upstream product

• 1423-27-4 2-(trifluoromethyl)phenylboronic acid 
• 106-40-1 4-bromo-aniline 

Relevant articles and documents

Novel 5-methyl-2-phenylphenanthridium derivatives as FtsZ-targeting antibacterial agents from structural simplification of natural product sanguinarine

A novel series of 5-methyl-2-phenylphenanthridium derivatives were displayed outstanding activity against a panel of antibiotic-sensitive and -resistant bacteria strains compared with their precursor sanguinarine, ciprofloxacin and oxacillin sodium. Compounds 7 l, 7m and 7n were found to display the most effective activity against five sensitive strains (0.06–2 μg/mL) and three resistant strains (0.25–4 μg/mL). The kinetic profiles indicated that compound 7l possessed the strongest bactericidal effect on S. aureus ATCC25923, with the MBC value of 16 μg/mL. The cell morphology and the FtsZ polymerization assays indicated that these compounds inhibited the bacterial proliferation by interfering the function of bacterial FtsZ. The SARs showed that all the 4-methyl-substituted 5-methyl-2-phenylphenanthridium subseries could be further investigated as the FtsZ-targeting antibacterial agents.

NOVEL HETEROCYCLIC AMIDE DERIVATIVES HAVING DIHYDROOROTATE DEHYDROGENASE INHIBITING ACTIVITY

Novel heterocyclic amide derivatives having pharmacological effects, that is, compounds represented by the general formula (1) or salts thereof: (1) wherein X1-X2 is S-CH2 or the like; R1 is alkyl or the like; p is 0 to 7; R2 is hydrogen, alkyl, or the like; R3 is hydrogen, alkyl, or the like; Y1-Y2 is CH=CH or the like; R4 is halogeno, alkyl, or the like; q is 0 to 4; and R5 is halogeno, hydrogen, alkyl, or the like.

OXYGEN OR SULFUR CONTAINING 5-MEMBERED HETEROAROMATICS AS FACTOR Xa INHIBITORS

The present application describes oxygen and sulfur containing heteroaromatics and derivatives thereof of formula (I), or pharmaceutically acceptable salt or prodrug forms thereof, wherein J is O or S and D may be C(=NH)NH2, which are useful as inhibitors of factor Xa.