209919-30-2

Basic information

• Product Name: 4-CHLORO-2-METHYLPHENYLBORONIC ACID
• Synonyms: AKOS BRN-0229;4-CHLORO-O-TOLUENEBORONIC ACID;4-CHLORO-2-METHYLBENZENEBORONIC ACID;4-CHLORO-2-METHYLPHENYLBORONIC ACID;4-Chloro-2-Methylphenylboronic;4-chloro-o-tolylboronic acid;4-Chloro-2-methylphenylboronic acid ,98%;4-Chloro-2-Methylphenylboronic Acid (contains varying aMounts of Anhydride)
• CAS NO: 209919-30-2
• Molecular Formula: C₇H₈BClO₂
• Molecular Weight: 170.4
• Product Categories: blocks;BoronicAcids;Aryl;Boronic acid;Organoborons
• Mol File: 209919-30-2.mol
• Article Data: 2

Chemical Properties

• Melting Point: 193-195°C
• Boiling Point: 314.9 °C at 760 mmHg
• Flash Point: 144.2 °C
• Appearance: /
• Density: 1.26 g/cm³
• Vapor Pressure: 0.000192mmHg at 25°C
• Refractive Index: 1.549
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 8.47±0.58(Predicted)
• CAS DataBase Reference: 4-CHLORO-2-METHYLPHENYLBORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-2-METHYLPHENYLBORONIC ACID(209919-30-2)
• EPA Substance Registry System: 4-CHLORO-2-METHYLPHENYLBORONIC ACID(209919-30-2)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36/37/39-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 209919-30-2(Hazardous Substances Data)

Usage

Chemical Properties

White solid

Uses

suzuki reaction

InChI:InChI=1/C7H8BClO2/c1-5-4-6(9)2-3-7(5)8(10)11/h2-4,10-11H,1H3

Upstream product

• 5419-55-6 Triisopropyl borate 
• 14495-51-3 2-bromo-5-chlorotoluene 

Downstream Products

• 872314-70-0 (E)-methyl-2-(4-chloro-2-methylphenyl)-3-methoxyacrylate 
• 895151-54-9 4-(4-chloro-2-methylphenyl)-2-phenylpyrimidine-5-carbaldehyde 
• 916220-05-8 4'-chloro-2'-methyl-biphenyl-3-carboxylic acid 
• 1238635-73-8 C₂₅H₃₀ClNO₂ 
• 1233078-55-1 C₁₈H₁₇ClO₂ 
• 1382838-45-0 N-(7-(4-chloro-2-methylphenyl)isoquinolin-3-yl)cyclopropanecarboxamide 
• 95-69-2 4-chloro-2-methylbenzeneamine 
• 1314118-99-4 C₂₇H₃₀ClN₃O₄ 
• 1334712-97-8 tert-butyl N-{4-[1-(4-chloro-2-methylphenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-cyclohexyl}carbamate 
• 1312077-77-2 7-(4-chloro-2-methylphenyl)-1,3,4,10-tetrahydro-2-thia-10-azaanthracen-9-one 
• 1310064-11-9 C₂₈H₂₆ClN₅O 
• 1202523-82-7 C₂₃H₂₂ClFN₄O₂ 
• 1208223-03-3 C₄₀H₃₉ClN₃O₅S^(1-)*Na⁽¹⁺⁾ 

Relevant articles and documents

Copper-Catalyzed Monoorganylation of Trialkyl Borates with Functionalized Organozinc Pivalates

Organozinc pivalates, a recently developed air- and moisture-stable organozinc species, were found for the first time as excellent organometallic species in the monoorganylation of trialkyl borates whereby boronic acids were prepared in high yields. The significant advantage of organozinc pivalates over another previously employed organometallic reagents, e. g., organolithium reagents, Grignard reagents and organozinc halides, is that the generation of multiorganylation byproducts such as borinic acids and trialkylboranes were completely suppressed. Additionally, the in situ generated boronates could be directly arranged into Suzuki-Miyaura type cross-coupling reactions to produce biaryls in high yields.