916220-05-8

Usage

Uses

Used in Pharmaceutical Synthesis:
3-(4-Chloro-2-methylphenyl)benzoic acid is utilized as a key intermediate in the synthesis of pharmaceuticals, contributing to the development of new drugs. Its specific structural features make it a valuable component in medicinal chemistry for creating molecules with desired therapeutic properties.
Used in Organic Chemical Reactions:
As an intermediate in organic chemical reactions, 3-(4-Chloro-2-methylphenyl)benzoic acid plays a crucial role in the formation of more complex organic compounds. Its reactivity and functional groups facilitate various synthetic pathways, expanding the scope of organic synthesis.
Used in Agrochemical Development:
3-(4-Chloro-2-methylphenyl)benzoic acid may find applications in the development of insecticides and herbicides. The presence of the chloro and methyl groups in the phenyl ring endows it with properties that could be harnessed to control or eliminate pests and weeds in agriculture, thereby increasing crop yields and protecting plants.
Used in Research and Industrial Applications:
In the field of organic chemistry, 3-(4-Chloro-2-methylphenyl)benzoic acid is a compound of interest for research and industrial applications. Its unique structure allows for exploration into new reaction mechanisms, the creation of novel materials, and the advancement of chemical processes in industry.

InChI:InChI=1/C14H11ClO2/c1-9-7-12(15)5-6-13(9)10-3-2-4-11(8-10)14(16)17/h2-8H,1H3,(H,16,17)

Upstream product

• 14495-51-3 2-bromo-5-chlorotoluene 
• 209919-30-2 4-chloro-2-methylphenylboronic acid 
• 618-51-9 3-Iodobenzoic acid 

Downstream Products

• 916219-71-1 (S)-3-[4-(4'-chloro-2'-methylbiphenyl-3-ylmethoxy)phenyl]-3-(1-methyl-1H-tetrazol-5-yl)propionic acid 

Relevant academic research and scientific papers

Discovery of the imidazole-derived GPR40 agonist AM-3189

As a follow-up to the GPR40 agonist AMG 837, which was evaluated in clinical trials for the treatment of type II diabetes, further optimization led to the discovery of AM-3189 (13k). AM-3189 is representative of a new class of compounds with minimal CNS penetration, superior pharmacokinetic properties and in vivo efficacy comparable to AMG 837.

Optimization of GPR40 agonists for type 2 diabetes

GPR40 (FFA1 and FFAR1) has gained significant interest as a target for the treatment of type 2 diabetes. TAK-875 (1), a GPR40 agonist, lowered hemoglobin A1c (HbA1c) and lowered both postprandial and fasting blood glucose levels in type 2 diabetic patient

The 1,3-diaminobenzene-derived aminophosphine palladium pincer complex {C6H3[NHP(piperidinyl)2]2Pd(Cl)} - A highly active Suzuki-Miyaura catalyst with excellent functional group tolerance

The rapidly prepared 1,3-diaminobenzenederived aminophosphine pincer complex {C6H3 [NHP(piperidinyl)2] 2Pd(Cl)} (1) is an effective Suzuki catalyst with excellent functional group tolerance. Side-product formations, such as homocoupling, debromation or protodeboration have only rarely been detected and if so, were in all cases below the 5% level. The presented reaction protocol is universally applicable. Experimental observations indicate that palladium nanoparticles are the catalytically active form of 1.

Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders

The present invention provides compounds useful, for example, for modulating insulin levels in a subject, having the general formula I: wherein Q is an optionally substituted phenyl; L is a bond or O; P is a benzene or an optionally substituted thiazole r