209958-55-4Relevant academic research and scientific papers
CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF
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Paragraph 0705, (2018/04/17)
Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.
Substituted biaryl pyrazoles as sodium channel blockers
Tyagarajan, Sriram,Chakravarty, Prasun K.,Zhou, Bishan,Taylor, Brett,Fisher, Michael H.,Wyvratt, Mathew J.,Lyons, Kathy,Klatt, Tracy,Li, Xiaohua,Kumar, Sanjeev,Williams, Brande,Felix, John,Priest, Birgit T.,Brochu, Richard M.,Warren, Vivien,Smith, McHardy,Garcia, Maria,Kaczorowski, Gregory J.,Martin, William J.,Abbadie, Catherine,McGowan, Erin,Jochnowitz, Nina,Parsons, William H.
scheme or table, p. 5480 - 5483 (2010/12/24)
Voltage-gated sodium channels have been shown to play a critical role in neuropathic pain. A series of low molecular weight biaryl substituted pyrazole carboxamides were identified with good in-vitro potency and in-vivo efficacy. Compound 26, a Nav1.7 blocker has excellent efficacy in the Chung model of neuropathic pain.
Structure-based design of novel guanidine/benzamidine mimics: Potent and orally bioavailable factor Xa inhibitors as novel anticoagulants
Lam, Patrick Y. S.,Clark, Charles G.,Li, Renhua,Pinto, Donald J. P.,Orwat, Michael J.,Galemmo, Robert A.,Fevig, John M.,Teleha, Christopher A.,Alexander, Richard S.,Smallwood, Angela M.,Rossi, Karen A.,Wright, Matthew R.,Bai, Stephen A.,He, Kan,Luettgen, Joseph M.,Wong, Pancras C.,Knabb, Robert M.,Wexler, Ruth R.
, p. 4405 - 4418 (2007/10/03)
As part of an ongoing effort to prepare orally active factor Xa inhibitors using structure-based drug design techniques and molecular recognition principles, a systematic study has been performed on the pharmacokinetic profile resulting from replacing the
