209959-15-9

Upstream product

• 367-57-7 1,1,1-Trifluoro-2,4-pentanedione 
• 218302-19-3 2-(6-amino-3-pyrimidinyl)benzene-tert-butylsulfonamide 
• 209917-93-1 1-(3-cyanophenyl)-3-trifluoromethylpyrazole-5-carboxylic acid 
• 209919-64-2 3-(5-(hydroxymethyl)-3-(trifluoromethyl )-1H-pyrazol-1-yl)benzonitrile 
• 27246-81-7 3-bromophenylhydrazine hydrochloride 

Downstream Products

• 209955-39-5 1-(3-amidinophenyl)-5-[[5-(2'-aminosulfonylphenyl)pyrimidin-2-yl]aminocarbonyl]-3-trifluoromethyl-pyrazole, Trifluoroacetic Acid Salt 

Relevant academic research and scientific papers

NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS

The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula (I) or pharmaceutically acceptable salt or prodrug forms thereof, wherein J is N or NH and D may be C(=NH)NH2, which are useful as inhibitors of factor Xa.

Discovery of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2′-(methylsulfonyl)-[1,1′-b iphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable inhibitor of blood coagulation factor Xa

Factor Xa (fXa) plays a critical role in the coagulation cascade, serving as the point of convergence of the intrinsic and extrinsic pathways. Together with nonenzymatic cofactor Va and Ca2+ on the phospholipid surface of platelets or endotheli

Nitrogen containing heteroaromatics as factor Xa inhibitors

The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein J is N or NH and D may be C(=NH)NH2, which are useful as inhibitors of factor Xa.