209971-44-8

Upstream product

• 36052-24-1 methyl 6-aminonicotinoate 
• 98-59-9 p-toluenesulfonyl chloride 
• 26218-78-0 methyl 6-bromonicotinate 
• 70-55-3 toluene-4-sulfonamide 

Downstream Products

• 209971-47-1 1-Carbamoylmethyl-6-[(E)-toluene-4-sulfonylimino]-1,6-dihydro-pyridine-3-carboxylic acid methyl ester 
• 1208250-24-1 methyl 1-(2-amino-2-oxoethyl)-6-(4-methylphenylsulfonamido)-1,6-dihydropyridine-3-carboxylate 
• 209971-61-9 3-(4-Chloro-phenylsulfanyl)-2-(2,2,2-trifluoro-acetylamino)-imidazo[1,2-a]pyridine-6-carboxylic acid methyl ester 
• 209971-62-0 3-(4-Fluoro-phenylsulfanyl)-2-(2,2,2-trifluoro-acetylamino)-imidazo[1,2-a]pyridine-6-carboxylic acid methyl ester 
• 209971-64-2 3-(3-Chloro-phenylsulfanyl)-2-(2,2,2-trifluoro-acetylamino)-imidazo[1,2-a]pyridine-6-carboxylic acid methyl ester 
• 209971-50-6 methyl 2-(2,2,2-trifluoroacetamido)imidazo[1,2-a]pyridine-6-carboxylate 

Relevant academic research and scientific papers

Copper-mediated n-heteroarylation of primary sulfonamides: Synthesis of mono-n-heteroaryl sulfonamides

"Figure Presented" We describe the coupling of primary sulfonamides and various halogenated heterocyclic cores, with an emphasis on 2-heteroaryl halides, via copper catalysis. These studies enabled the synthesis of many new mono-N-heteroaryl sulfonamides.

cMET INHIBITORS

Compounds of the following formula are provided for use with cMET: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

Chemoselective arylsulfenylation of 2-aminoimidazo[1,2-α]pyridines by phenyliodine(III) bis(trifiuoroacetate) (PIFA)

A series of 2-(trifluoroacetamido)imidazo[1,2-a]pyridines was prepared and treated with phenyliodine(III) bis(trifluoroacetate) (PIFA) in the presence of a variety of thiols leading chemoselectively to the corresponding 3-sulfides. Exposure of these adducts to silica gel in MeOH/CH2Cl2 provides a convenient method for the cleavage of the trifluoroacetamide group.