209984-58-7 Usage
General Description
LY-411575 (isoMer 1) is a chemical compound that acts as a potent and selective inhibitor of gamma-secretase, an enzyme involved in the cleavage of amyloid precursor protein and the production of amyloid-beta peptides, which are implicated in the pathogenesis of Alzheimer's disease. It has been shown to effectively reduce the production of amyloid-beta peptides in a dose-dependent manner in vitro and in vivo, and it has exhibited promising results in preclinical studies as a potential therapeutic agent for the treatment of Alzheimer's disease. Additionally, LY-411575 (isoMer 1) has demonstrated good oral bioavailability and pharmacokinetic properties, making it a promising candidate for further development as a treatment for Alzheimer's disease and other neurodegenerative disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 209984-58-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,9,9,8 and 4 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 209984-58:
(8*2)+(7*0)+(6*9)+(5*9)+(4*8)+(3*4)+(2*5)+(1*8)=177
177 % 10 = 7
So 209984-58-7 is a valid CAS Registry Number.
209984-58-7Relevant articles and documents
A multigram chemical synthesis of the γ-secretase inhibitor LY411575 and its diastereoisomers
Fauq, Abdul H.,Simpson, Katherine,Maharvi, Ghulam M.,Golde, Todd,Das, Pritam
, p. 6392 - 6395 (2008/09/16)
An improved chemical synthesis of N-2((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-l-alaninamide (LY411,575, 9a), a known γ-secretase inhibitor, is described. The key synthetic steps, which
