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LY-411575 (isoMer 1) is a chemical compound that functions as a potent and selective inhibitor of gamma-secretase, an enzyme critical in the cleavage of amyloid precursor protein and the generation of amyloid-beta peptides. These peptides are associated with the development of Alzheimer's disease. LY-411575 (isoMer 1) has demonstrated its effectiveness in reducing amyloid-beta peptide production in a dose-dependent manner both in vitro and in vivo, showing promise as a potential therapeutic agent for Alzheimer's disease treatment. Its good oral bioavailability and favorable pharmacokinetic properties position it as a strong candidate for further development for the treatment of Alzheimer's disease and other neurodegenerative disorders.

209984-58-7

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209984-58-7 Usage

Uses

Used in Pharmaceutical Industry:
LY-411575 (isoMer 1) is used as a therapeutic agent for the treatment of Alzheimer's disease due to its ability to inhibit the production of amyloid-beta peptides, which are implicated in the pathogenesis of the disease.
Used in Neurodegenerative Disorder Research:
In the field of neurodegenerative disorder research, LY-411575 (isoMer 1) is utilized as a research tool to study the role of gamma-secretase in the development of Alzheimer's disease and to explore its potential as a treatment for other related disorders.
Used in Drug Development:
LY-411575 (isoMer 1) is employed in drug development as a lead compound for the creation of new medications targeting the inhibition of gamma-secretase, aiming to provide novel treatment options for Alzheimer's disease and potentially other neurodegenerative conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 209984-58-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,9,9,8 and 4 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 209984-58:
(8*2)+(7*0)+(6*9)+(5*9)+(4*8)+(3*4)+(2*5)+(1*8)=177
177 % 10 = 7
So 209984-58-7 is a valid CAS Registry Number.

209984-58-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name N2-((2R)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-L-alaninamide

1.2 Other means of identification

Product number -
Other names N2-((2R)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-L-alaninamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:209984-58-7 SDS

209984-58-7Downstream Products

209984-58-7Relevant academic research and scientific papers

A multigram chemical synthesis of the γ-secretase inhibitor LY411575 and its diastereoisomers

Fauq, Abdul H.,Simpson, Katherine,Maharvi, Ghulam M.,Golde, Todd,Das, Pritam

, p. 6392 - 6395 (2008/09/16)

An improved chemical synthesis of N-2((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-l-alaninamide (LY411,575, 9a), a known γ-secretase inhibitor, is described. The key synthetic steps, which

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