253324-50-4

Upstream product

• 209984-33-8 (S)-5-(N-Boc-L-alaninyl)amino-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one 
• 209984-34-9 (R)-5-(N-Boc-L-alaninyl)amino-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one 
• 683277-83-0 (2'-azido-biphenyl-2-yl)-acetic acid pentafluorophenyl ester 
• 209984-31-6 7-methyl-5-oximo-5,7-dihydro-6H-dibenz[b,d]azepin-6-one 
• 683277-82-9 (2'-azido-biphenyl-2-yl)-acetic acid 
• 213024-76-1 7-amino-5-methyl-5H-dibenzo[b,d]azepin-6(7H)-one hydrochloride 
• 683277-81-8 (2'-azido-biphenyl-2-yl)-acetonitrile 
• 209984-30-5 N-methyl-5H-dibenzo[b,d]azepin-6(7H)-one 
• 325141-76-2 2-{2'-amino-[1,1'-biphenyl]-2-yl}acetonitrile 
• 615-36-1 2-bromoaniline 
• 40400-15-5 2-(2-iodophenyl)acetonitrile 
• 20011-90-9 5H,7H-dibenzo[b,d]azepin-6-one 
• 228877-28-9 5-(N-Boc-L-alaninyl)amino-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one 

Downstream Products

• 209984-68-9 7-(S)-(N'-((S)-(+)-2-hydroxy-3-methylbutyryl)-L-alaninyl)amino-5-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one 

Relevant academic research and scientific papers

A multigram chemical synthesis of the γ-secretase inhibitor LY411575 and its diastereoisomers

An improved chemical synthesis of N-2((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-l-alaninamide (LY411,575, 9a), a known γ-secretase inhibitor, is described. The key synthetic steps, which

Highly efficient synthesis of medium-sized lactams via intramolecular Staudinger-aza-Wittig reaction of ω-azido pentafluorophenyl ester: Synthesis and biological evaluation of LY411575 analogues

A highly efficient method for the synthesis of medium-sized lactams based on intramolecular Staudinger-aza-Wittig reaction of ω-azido pentafluorophenyl ester has been developed. A variety of 7-10 membered lactams were synthesized in excellent yields. Appl