209991-63-9

Basic information

• Product Name: 2,4,6-Trifluorophenylacetic acid
• Synonyms: RARECHEM AL BO 0511;BUTTPARK 145\04-86;2,4,6-TRIFLUOROPHENYLACETIC ACID;2,4,6-Trifluorophenylacetic acid 97%;2,4,6-Trifluorophenylaceticacid97%;2-(2,4,6-trifluorophenyl)acetic acid;2,4,7-Trifluorophenyl acetic acid;2,4,6-Trifluorobenzeneacetic acid
• CAS NO: 209991-63-9
• Molecular Formula: C8H5F3O2
• Molecular Weight: 190.12
• Product Categories: Aromatic Phenylacetic Acids and Derivatives;Phenylacetic acid;Miscellaneous;Fluorine series
• Mol File: 209991-63-9.mol

Chemical Properties

• Melting Point: 110-112
• Boiling Point: 242.113 °C at 760 mmHg
• Flash Point: 100.226 °C
• Appearance: /
• Density: 1.468 g/cm³
• Vapor Pressure: 0.0186mmHg at 25°C
• Refractive Index: 1.488
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.70±0.10(Predicted)
• CAS DataBase Reference: 2,4,6-Trifluorophenylacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,6-Trifluorophenylacetic acid(209991-63-9)
• EPA Substance Registry System: 2,4,6-Trifluorophenylacetic acid(209991-63-9)

Safety Data

• Hazard Codes: Xi,T+
• HazardClass: IRRITANT
• Hazardous Substances Data: 209991-63-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,4,6-Trifluorophenylacetic acid is used as an intermediate in the synthesis of pharmaceuticals for its anti-inflammatory and analgesic properties. It plays a crucial role in the development of medications aimed at treating inflammatory conditions.
Used in Agrochemical Industry:
In the agrochemical sector, 2,4,6-Trifluorophenylacetic acid serves as an intermediate in the production of various agrochemicals, contributing to the development of products that enhance crop protection and yield.
Used in Dye and Pigment Production:
2,4,6-Trifluorophenylacetic acid is utilized in the manufacturing process of dyes and pigments, where its chemical properties contribute to the creation of a diverse range of colorants for various applications.
Used in Industrial Chemical Production:
2,4,6-Trifluorophenylacetic acid is also employed in the production of other industrial chemicals, highlighting its versatility and importance in multiple chemical synthesis processes.

InChI:InChI=1/C8H5F3O2/c9-4-1-6(10)5(3-8(12)13)7(11)2-4/h1-2H,3H2,(H,12,13)

Upstream product

• 2367-76-2 2,4,6-trifluorobromobenzene 
• 372-38-3 1,3,5-trifluorobenzene 
• 262609-07-4 diethyl (2,4,6-trifluoro-phenyl)-malonate 

Downstream Products

• 716324-85-5 8-hydroxy-7-(2,4,6-trifluorophenyl)pyrido[2,3-b]pyrazin-6(5H)-one 
• 716324-86-6 6,8-dichloro-7-(2,4,6-trifluorophenyl)pyrido[2,3-b]pyrazine 
• 1041769-17-8 4-(4-bromophenyl)-5-(2,4,6-trifluorophenyl)-1,2-dihydro-pyridazine-3,6-dione 
• 1041769-15-6 4-(4-bromophenyl)-3,6-dichloro-5-(2,4,6-trifluorophenyl)-pyridazine 
• 1041769-21-4 4-(4-bromophenyl)-3,6-difluoro-5-(2,4,6-trifluorophenyl)-pyridazine 
• 1041769-19-0 4-(4-bromophenyl)-6-chloro-3-methoxy-5-(2,4,6-trifluorophenyl)-pyridazine 
• 1020730-94-2 3-chloro-6-methyl-5-naphthalen-2-yl-4-(2,4,6-trifluorophenyl)-pyridazine 
• 915030-31-8 N-(5-chloro-1,3-thiazol-2-yl)-1-methyl-5-{[(2,4,6-trifluorophenyl)acetyl]amino}-1H-imidazole-4-carboxamide 
• 915030-30-7 3-methyl-5-(2,4,6-trifluorobenzyl)imidazo[4,5-d][1,3]oxazin-7(3H)-one 
• 1588945-09-8 2-(2,4-difluoro-6-(2-((1R,2R)-2-(piperidin-4-yl)cyclopropyl)ethoxy)phenyl)-N,N-dimethylacetamide 
• 1588945-08-7 benzyl 4-((1R,2R)-2-(2-(2-(2-(dimethylamino)-2-oxoethyl)-3,5-difluorophenoxy)ethyl)cyclopropyl)piperidine-1-carboxylate 
• 1588944-86-8 N,N-dimethyl-2-(2,4,6-trifluorophenyl)acetamide 

Relevant articles and documents

A new Knoevenagel-type synthesis of fully substituted γ- hydroxybutenolides

The synthesis of fully substituted γ-hydroxybutenolides is possible by a Knoevenagel-type ring condensation of α-methyleneketones and α-ketoesters under basic conditions. This novel transformation allowed the preparation of di-aryl/heteroaryl substituted hydroxyfuranones, such as 20 and 27, which are important intermediates for pyridazine fungicides. As it turned out, a whole range of different substituents, such as alkyl, cycloalkyl, aryl, heteroaryl and ester groups could be linked to the butenolide scaffold, demonstrating the broad scope of the novel cyclization.