2367-76-2

Basic information

• Product Name: 1-Bromo-2,4,6-trifluorobenzene
• Synonyms: Benzene, 2-bromo-1,3,5-trifluoro-;2,4,6-Trifluoro-1-bromobenzene;1-Bromo-2,4,6-trifluorobenzene 99%;1-Bromo-2,4,6-trifluorobenzene99%;2-BROMO-1,3,5-TRIFLUOROBENZENE, 98+%;1,3,5-Trifluoro-2-bromobenzene;2,4,6-Trifluorophenyl bromide;1-Bromo-2,4,6-triflu
• CAS NO: 2367-76-2
• Molecular Formula: C₆H₂BrF₃
• Molecular Weight: 210.98
• EINECS: 219-125-9
• Product Categories: Fluorobenzene;Aromatic Hydrocarbons (substituted) & Derivatives;Miscellaneous;Aryl;C6;Halogenated Hydrocarbons
• Mol File: 2367-76-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 3.5 °C(lit.)
• Boiling Point: 140.5 °C(lit.)
• Flash Point: 137 °F
• Appearance: clear colorless liquid
• Density: 1.79 g/mL at 25 °C(lit.)
• Vapor Pressure: 1.7mmHg at 25°C
• Refractive Index: n20/D 1.485(lit.)
• Storage Temp.: Flammables area
• Solubility: Chloroform, Ethyl Acetate
• BRN: 2502668
• CAS DataBase Reference: 1-Bromo-2,4,6-trifluorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Bromo-2,4,6-trifluorobenzene(2367-76-2)
• EPA Substance Registry System: 1-Bromo-2,4,6-trifluorobenzene(2367-76-2)

Safety Data

• Hazard Codes: Xi,F
• Statements: 36/37/38-10
• Safety Statements: 26-37/39-16
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 2367-76-2(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless liquid

General Description

1-Bromo-2,4,6-trifluorobenzene exhibits packing polymorphism in two nonidentical solid-state phases. 1-Bromo-2,4,6-trifluorobenzene participates in Pd-catalyzed oxidative Heck reaction with allyl ester.

InChI:InChI=1/C6H2Cl2F2/c7-4-1-3(9)2-5(8)6(4)10/h1-2H

Upstream product

• 13656-36-5 3,5-dichloro-2,4,6-trifluorobenzoic acid 
• 2368-53-8 1,3-dichloro-2,4,6-trifluorobenzene 
• 399-36-0 N-(2,4-difluoro-phenyl)-acetamide 
• 372-39-4 3,5-difluoroaniline 
• 364-30-7 2-amino-3,5-difluoronitrobenzene 
• 2265-94-3 1,3-difluoro-5-nitrobenzene 
• 372-38-3 1,3,5-trifluorobenzene 

Downstream Products

• 262609-07-4 diethyl (2,4,6-trifluoro-phenyl)-malonate 
• 114318-52-4 2,4,6-trifluorophenylmagnesium bromide 
• 182482-25-3 2,4,6-trifluorophenylboronic acid 
• 1352658-05-9 1-bromo-2-[4-(2,4,6-trifluorophenyl)butoxy]benzene 
• 28314-80-9 2,4,6-trifluorobenzoic acid 
• 1332334-09-4 3-(2,4,6-trifluorophenyl)-1H-pyrrole 
• 631899-57-5 (2R,3R,4S,5S)-3,4-Bis-benzyloxy-2-benzyloxymethyl-5-(2,4,6-trifluoro-phenyl)-tetrahydro-furan 
• 1278509-50-4 2-O-[(tert-butyl)-dimethylsilyl]-1-deoxy-5-O-(4,4'-dimethoxytrityl)-3-(2-cyanoethyl-N,N-diisopropylphosphoramidite)-1-(2,4,6-trifluorophenyl)-β-D-ribofuranose 
• 1278509-45-7 2-O-[(tert-butyl)-dimethylsilyl]-1-deoxy-5-O-(4,4'-dimethoxytrityl)-1-(2,4,6-trifluorophenyl)-β-D-ribofuranose 
• 1278509-43-5 1-deoxy-5-O-(4,4'-dimethoxytrityl)-1-(2,4,6-trifluorophenyl)-β-D-ribofuranose 
• 473253-20-2 2-(2,4,6-trifluorophenyl)-malonic acid dimethyl ester 
• 1197029-27-8 N₄-(2-bromo-3,5-difluorophenyl)-l3-nitropyridine-2,4-diamine 
• 918418-35-6 diethyl 2-hydroxy-2-(2',4',6'-trifluorophenyl)malonate 
• 910649-07-9 5-(2,4,6-trifluorophenyl)-3-pyridinyl 2,3,4-tri-O-acetyl-5-thio-β-D-xylo-pyranoside 

Relevant articles and documents

PROCESS FOR PREPARATION OF HALO SUBSTITUTED BENZOIC ACID COMPOUND AND INTERMEDIATES THEREOF

The present invention provides a process for preparation of halo substituted benzoic acid compound of Formula (1) and intermediates thereof.

Method for the production of substituted 2-aryl malonic acid esters

The present invention relates to a process for preparing substituted 2-arylmalonic esters of the general formula I in which R is C1-C6-alkyl or C1-C4-alkoxy-C1-C4-alkyl; Ar is phenyl or a heteroaromatic 5- or 6-membered ring; where each carbon atom present in the radicals mentioned above optionally carries a substituent RA; RA is F, Cl, CN, NO2, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, etc., or two adjacent substituents RA together with the carbon atoms to which they are attached form a ring; and where a malonic ester is reacted with a base and an aryl bromide in the presence of a copper salt, which comprises employing from 0.1 to 0.65 molar equivalents of the base per molar equivalent of the malonic ester.

Method for producing tetrakis ( fluoroaryl) borate-magnesium compound

Fluoroaryl magnesium halide is reacted with a boron compound so that a molar ratio of the fluoroaryl magnesium halide to the boron compound is not less than 3.0 and not more than 3.7, so as to produce a tetrakis (fluoroaryl) borate·magnesium compound. With this method, there occurs no hydrogen fluoride which corrodes a producing apparatus and requires troublesome waste water treatment.