209994-99-0

Basic information

• Product Name: 7-(L-alaninyl)-amino-5-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• CAS NO: 209994-99-0
• Molecular Weight: 309.368
• Mol File: 209994-99-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 7-(L-alaninyl)-amino-5-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(L-alaninyl)-amino-5-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one(209994-99-0)
• EPA Substance Registry System: 7-(L-alaninyl)-amino-5-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one(209994-99-0)

Safety Data

• Hazardous Substances Data: 209994-99-0(Hazardous Substances Data)

Upstream product

• 325141-76-2 2-{2'-amino-[1,1'-biphenyl]-2-yl}acetonitrile 
• 683277-83-0 (2'-azido-biphenyl-2-yl)-acetic acid pentafluorophenyl ester 
• 209984-31-6 7-methyl-5-oximo-5,7-dihydro-6H-dibenz[b,d]azepin-6-one 
• 683277-82-9 (2'-azido-biphenyl-2-yl)-acetic acid 
• 213024-76-1 7-amino-5-methyl-5H-dibenzo[b,d]azepin-6(7H)-one hydrochloride 
• 683277-81-8 (2'-azido-biphenyl-2-yl)-acetonitrile 
• 209984-30-5 N-methyl-5H-dibenzo[b,d]azepin-6(7H)-one 
• 615-36-1 2-bromoaniline 
• 40400-15-5 2-(2-iodophenyl)acetonitrile 
• 20011-90-9 5H,7H-dibenzo[b,d]azepin-6-one 
• 228877-28-9 5-(N-Boc-L-alaninyl)amino-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one 

Downstream Products

• 959977-19-6 N₂-(2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N₁-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-L-alaninamide 

Relevant articles and documents

A multigram chemical synthesis of the γ-secretase inhibitor LY411575 and its diastereoisomers

An improved chemical synthesis of N-2((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-l-alaninamide (LY411,575, 9a), a known γ-secretase inhibitor, is described. The key synthetic steps, which