213024-76-1

Basic information

• Product Name: 6H-DIBENZ[B,D]AZEPIN-6-ONE, 7-AMINO-5,7-DIHYDRO-5-METHYL-
• Synonyms: 6H-DIBENZ[B,D]AZEPIN-6-ONE, 7-AMINO-5,7-DIHYDRO-5-METHYL-;7-AMino-5-Methyl-5H-dibenzo[b,d]azepin-6(7H)-one;7-AMino-5-Methyl-5H,7H-dibenzo[b,d]azepin-6-one;7-amino-5-methyl-5,7-dihydro-6H-dibenzo[b,d]azepin-6-one
• CAS NO: 213024-76-1
• Molecular Formula: C₁₅H₁₄N₂O
• Molecular Weight: 238.289
• Mol File: 213024-76-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 506.67°C at 760 mmHg
• Flash Point: 260.225°C
• Appearance: /
• Density: 1.198g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.625
• CAS DataBase Reference: 6H-DIBENZ[B,D]AZEPIN-6-ONE, 7-AMINO-5,7-DIHYDRO-5-METHYL-(CAS DataBase Reference)
• NIST Chemistry Reference: 6H-DIBENZ[B,D]AZEPIN-6-ONE, 7-AMINO-5,7-DIHYDRO-5-METHYL-(213024-76-1)
• EPA Substance Registry System: 6H-DIBENZ[B,D]AZEPIN-6-ONE, 7-AMINO-5,7-DIHYDRO-5-METHYL-(213024-76-1)

Safety Data

• Hazardous Substances Data: 213024-76-1(Hazardous Substances Data)

Usage

General Description

6H-Dibenz[b,d]azepin-6-one, 7-amino-5,7-dihydro-5-methyl- is a chemical compound with a molecular formula of C15H16N2O. It is a heterocyclic compound with a seven-membered ring structure. 6H-Dibenz[b,d]azepin-6-one, 7-amino-5,7-dihydro-5-methyl- is often used in the pharmaceutical industry, where it has been found to possess various biological activities, including antipsychotic, antihistaminic, and analgesic properties. It is also used as a research chemical in the development of new drugs for the treatment of psychiatric and neurological disorders. Additionally, it has been studied for its potential anti-inflammatory and antitumor activities. Overall, 6H-Dibenz[b,d]azepin-6-one, 7-amino-5,7-dihydro-5-methyl- is a versatile chemical with a wide range of potential applications in the fields of medicine and pharmaceuticals.

InChI:InChI=1/C15H14N2O/c1-17-13-9-5-4-7-11(13)10-6-2-3-8-12(10)14(16)15(17)18/h2-9,14H,16H2,1H3

Upstream product

• 955879-95-5 N-([1,1'-biphenyl]-2-yl)-2-chloro-N-methylacetamide 
• 14925-09-8 2-(N-methylamino)-1,1'-biphenyl 
• 90-41-5 2-phenylaniline 
• 1243328-12-2 C₂₉H₂₆N₂O 
• 683277-83-0 (2'-azido-biphenyl-2-yl)-acetic acid pentafluorophenyl ester 
• 683277-82-9 (2'-azido-biphenyl-2-yl)-acetic acid 
• 683277-81-8 (2'-azido-biphenyl-2-yl)-acetonitrile 
• 209984-30-5 N-methyl-5H-dibenzo[b,d]azepin-6(7H)-one 
• 325141-76-2 2-{2'-amino-[1,1'-biphenyl]-2-yl}acetonitrile 
• 615-36-1 2-bromoaniline 
• 40400-15-5 2-(2-iodophenyl)acetonitrile 
• 20011-90-9 5H,7H-dibenzo[b,d]azepin-6-one 
• 209984-31-6 7-methyl-5-oximo-5,7-dihydro-6H-dibenz[b,d]azepin-6-one 

Downstream Products

• 209994-99-0 7-(L-alaninyl)-amino-5-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one 
• 209984-55-4 (S,S)-7-amino-5-methyl-5H-dibenzo[b,d]azepin-6(7H)-one hydrochloride 
• 209993-15-7 7-{N'-(3,5-difluorophenylacetyl)-4-ethylnorleucinyl}amino-5-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one 
• 209984-33-8 (S)-5-(N-Boc-L-alaninyl)amino-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one 
• 209984-34-9 (R)-5-(N-Boc-L-alaninyl)amino-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one 
• 959977-20-9 C₂₃H₂₀N₂O₃ 
• 959977-21-0 C₂₃H₂₀N₂O₃ 

Relevant articles and documents

New flurbiprofen derivatives: Synthesis, membrane affinity and evaluation of in vitro effect on β-amyloid levels

Alzheimer′s disease (AD) is characterized by irreversible and progressive loss of memory and cognition and profound neuronal loss. Current therapeutic strategies for the treatment of AD have been directed to a variety of targets with the aim of reversing or preventing the disease but, unfortunately, the available treatments often produce no significant clinical benefits. During the last decades compounds that inhibit or modulate γ-secretase, reducing β amyloid (Aβ) levels, have been considered as potential therapeutics for AD. Among these the (R)-enantiomer of flurbiprofen (FLU) seems to be very promising, but it shows low brain penetration. In this study, in order to improve the properties of FLU against Alzheimer′s pathogenesis we synthesized some novel FLU lipophilic analogues. Lipophilicity of the new molecules has been characterized in terms of clogP, log KC18/W and log K IAM/W values. Permeability has been determined in both gastrointestinal PAMPA (PAMPA-GI) at different pH values and in brain blood barrier PAMPA (PAMPA-BBB) models. They were also tested for their ability to inhibit in vitro γ-secretase activity using rat CTXTNA2 astrocytes. Interestingly, the investigated molecules demonstrated to reduce Aβ 42 levels without affecting the amyloid precursor protein APP level in a clear concentrations-dependent manner.

Synthesis and axial chirality of an enantiopure aminodibenzazepinone

A route for the synthesis of (S,S)-7-amino-5-methyl-5H-dibenzo[b,d]azepin-6(7H)-one hydrochloride is disclosed. The synthesis includes a Friedel-Crafts alkylation to form the seven-membered ring and a highly efficient classical resolution. Additional stud

Highly efficient synthesis of medium-sized lactams via intramolecular Staudinger-aza-Wittig reaction of ω-azido pentafluorophenyl ester: Synthesis and biological evaluation of LY411575 analogues

A highly efficient method for the synthesis of medium-sized lactams based on intramolecular Staudinger-aza-Wittig reaction of ω-azido pentafluorophenyl ester has been developed. A variety of 7-10 membered lactams were synthesized in excellent yields. Appl