21005-45-8

Basic information

• Product Name: 1-Methyl-1H-indole-6-carbaldehyde
• Synonyms: 1-Methyl-1H-indol-6-carbaldehyde;6-Formyl-1-methylindole;1-Methyl-1H-indole-6-carboxaldehyde 97%;1-METHYL-1H-INDOLE-6-CARBALDEHYDE;1H-Indole-6-carboxaldehyde, 1-methyl- (9CI);1-Methyl-1H-Indole-6-carboxaldehyde;1-Methylindole-6-carbaldehyde;1-methyl-1H-indole-6-carbaldehyde(SALTDATA: FREE)
• CAS NO: 21005-45-8
• Molecular Formula: C₁₀H₉NO
• Molecular Weight: 159.18456
• Product Categories: ALDEHYDE;Carbonyl Compounds;Heterocycles
• Mol File: 21005-45-8.mol
• Article Data: 10

Chemical Properties

• Melting Point: 81 °C
• Boiling Point: 318.7 °C at 760 mmHg
• Flash Point: 146.5 °C
• Appearance: /
• Density: 1.10±0.1 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.000356mmHg at 25°C
• Refractive Index: 1.585
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Methyl-1H-indole-6-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-1H-indole-6-carbaldehyde(21005-45-8)
• EPA Substance Registry System: 1-Methyl-1H-indole-6-carbaldehyde(21005-45-8)

Safety Data

• Hazard Codes: Xi
• Statements: 41-52-36
• Safety Statements: 26-39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 21005-45-8(Hazardous Substances Data)

Usage

General Description

1-Methyl-1H-indole-6-carbaldehyde, also known as 6-Formyl-1-methylindole, is a chemical compound with the molecular formula C10H9NO. It is an aldehyde derivative of indole, a heterocyclic compound commonly found in various natural products and pharmaceuticals. 1-Methyl-1H-indole-6-carbaldehyde is commonly used as a building block in the synthesis of pharmaceutical and agrochemical products. It is also known for its potential use in the development of novel drugs due to its ability to interact with biological targets. Additionally, 1-Methyl-1H-indole-6-carbaldehyde exhibits interesting photophysical properties, making it useful in the development of new materials for electro-optical devices. Overall, it is a versatile compound with various potential applications in the fields of medicinal chemistry, materials science, and organic synthesis.

InChI:InChI=1/C10H9NO/c1-11-5-4-9-3-2-8(7-12)6-10(9)11/h2-7H,1H3

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 125872-95-9 6-bromo-1-methyl-1H-indole 
• 1075-26-9 6-(hydroxymethyl)indole 
• 20996-87-6 1-methyl-1H-indole-6-carbonitrile 
• 1196-70-9 indole-6-carboxaldehyde 
• 74-88-4 methyl iodide 
• 32989-68-7 trans-4-(β-dimethylaminovinyl)-3-nitrobenzaldehyde 

Relevant articles and documents

NOVEL COMPOUNDS AS INHIBITORS OF HISTONE DEACETYLASE 6 AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention relates to a new compound having an inhibitory activity of histone deacetylase 6 (HDAC6), stereoisomers thereof, pharmaceutically acceptable salts thereof, a use thereof in the preparation of a drug, a pharmaceutical composition comprising them, a prophylactic or therapeutic method corresponding, and a method of preparing a new derivative 1,3,4-oxadiazole triazol, a novel compound having selective HDAC6 inhibitory activity being represented by the following chemical formula I.

Novel achiral indole-substituted titanocenes: Synthesis and preliminary cytotoxicity studies

A series of eight new titanocene dichloride derivatives has been synthesised and characterized. Four compounds from the series are lypophilic indole-functionalised titanocenes and four are hydrochloride salts of their dimethylaminomethyl-functionalised counterparts, which are water soluble. The compounds were tested for their in vitro cytotoxicities against the human kidney cancer cell line CAKI-1 and their results are compared with previously synthesised structural analogues. Surprisingly, two of the compounds showed no activity against the CAKI-1 cell line; however six compounds exhibited medium to high potency with IC50 values as low as 7.0 μM. These six complexes were tested further on this cell line using the co-solvent Soluphor P, which has been shown to improve both solubility and cytotoxicity of similar complexes. One of the compounds carrying a N-methylindole-substituent was obtained in the form of single crystals and allowed for the characterisation by X-ray crystallography; the compound crystallised in the space group P21/n (#14) with four molecules present in the monoclinic unit cell.

OXAZOLYL PIPERIDINE MODULATORS OF FATTY ACID AMIDE HYDROLASE

Certain oxazolyl piperidine compounds are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity. Thus, the compounds may be administered to treat, e.g., anxiety, pain, inflammation, sleep disorders, eating disorders, or movement disorders (such as multiple sclerosis).