210169-19-0

Basic information

• Product Name: Pyridine,3,5-difluoro-4-(trimethylsilyl)-(9CI)
• Synonyms: Pyridine,3,5-difluoro-4-(trimethylsilyl)-(9CI)
• CAS NO: 210169-19-0
• Molecular Formula: C₈H₁₁F₂NSi
• Molecular Weight: 187.2619464
• Product Categories: SILYL
• Mol File: 210169-19-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pyridine,3,5-difluoro-4-(trimethylsilyl)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine,3,5-difluoro-4-(trimethylsilyl)-(9CI)(210169-19-0)
• EPA Substance Registry System: Pyridine,3,5-difluoro-4-(trimethylsilyl)-(9CI)(210169-19-0)

Safety Data

• Hazardous Substances Data: 210169-19-0(Hazardous Substances Data)

Upstream product

• 30841-93-1 2,4,6-tribromo-3,5-difluoropyridine 
• 700-16-3 Pentafluoropyridine 
• 75-77-4 chloro-trimethyl-silane 
• 71902-33-5 3,5-difluoropyridine 

Relevant articles and documents

PYRAZOLYL-AMINO-SUBSTITUTED PYRIMIDINES AND THEIR USE FOR THE TREATMENT OF CANCER

The present invention relates to compounds of Formula (I) and to their pharmaceutical compositions, and to their methods of use. These compounds provide a treatment for myeloproliferative disorders and cancer.

Polyhalogenated heterocyclic compounds. Part 42. Fluorinated nitrogen heterocycles with unusual substitution patterns

Reductive replacement of fluorine in 3,5-dichloro-2,4,6-trifluoropyridine 2a and pentafluoropyridine 2 using DIBAL and LAH leads to useful syntheses of fluoro and chlorofluoro pyridine derivatives. Replacement of fluorine by bromine using a mixture of HBr and AlBr3 is extremely efficient, giving excellent routes to 2,4,6-tribromo-3,5-difluoropyridine 3. Bromofluoro-pyrimidine and -quinoxaline derivatives have also been efficiently synthesised from perfluorinated precursors. Catalytic hydrogenation of bromofluoro heterocycles gives high yields of the corresponding fluorinated heterocycles. Reactions of nucleophiles with 3 gives surprising results. Soft nucleophiles, e.g. PhSNa displace bromine whereas hard nucleophiles, e.g. MeONa, displace fluorine. British Crown Copyright 1998, Defence Evaluation and Research Agency. Published by the Royal Society of Chemistry with the permission of the controller of Her Britannic Majesty's Stationery Office.