210232-93-2

Upstream product

• 14003-18-0 ethyl 2-(2-oxoindolin-3-ylidene)cyanoacetate 
• 504-02-9 1,3-cylohexanedione 
• 6532-16-7 1-(4-morpholinylmethyl)-1H-indole-2,3-dione 
• 105-56-6 ethyl 2-cyanoacetate 
• 91-56-5 indole-2,3-dione 
• 14003-19-1 ethyl cyano-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)acetate 

Relevant academic research and scientific papers

One-pot synthesis of spirooxindole derivatives catalyzed by lipase in the presence of water

A facile one-pot synthesis route to spirooxindole derivatives was developed by combining the three types of catalytic activities of lipase from porcine pancreas (PPL) in the presence of water, i.e., the Knoevengel condensation, Michael addition and cyclization. PPL showed excellent catalytic activity and have a good adaptability to different substrates in the reaction. All the reactions go smoothly and provide spirooxindole derivatives with high yield under the mild conditions. This lipase-catalyzed multistep conversion method has provided a new strategy to synthesize spirooxindole derivatives and expanded the application of biocatalysts.

Magnetic calcined oyster shell functionalized with taurine immobilized on β-cyclodextrin (Fe3O4/COS@β-CD-SO3H NPs) as green and magnetically reusable nanocatalyst for efficient and rapid synthesis of spirooxindoles

Abstract: Magnetic calcined oyster shell functionalized with taurine immobilized on β-cyclodextrin (Fe3O4/COS@β-CD-SO3H NPs) was prepared as a new stable, long-lived, highly efficient, and exceptional reusable magnetic nan

A simple and one-pot synthesis of tetrahydrobenzo[b]pyrans and spirooxindoles catalyzed by H-Fe3 O4 @DA-SO3 h as an efficient, light and reusable nanocatalyst

Aim and Objective: One of the principles of green chemistry is using inexpensive reagents and catalysts to design green route for synthesis of organic compounds. Recently magnetic nanoparticles have provided a considerable merits. In this study, hollow Fe

Caspian Isinglass, a versatile and sustainable biocatalyst for domino synthesis of spirooxindoles and spiroacenaphthylenes in water

Abstract: Isinglass, derived from swim bladders of Caspian Sea fish and consisting predominantly of protein collagen, was found to be an effective, easily accessible heterogeneous biocatalyst for the synthesis of biologically important functionalized spir

Synthesis of functionalized chromene and spirochromenes using L-proline-melamine as highly efficient and recyclable homogeneous catalyst at room temperature

An efficient and recyclable homogeneous catalyst is developed using commercially cheap L-proline and melamine for the synthesis of chromenes and spirochromenes (spirooxindoles) via multicomponent reactions at room temperature. Systematic studies were conducted in order to achieve desired reactivity and recyclability of the catalyst using various α-amino acids and aromatic amines as donor-acceptor pairs. Among the screened combinations, L-proline and melamine (3:1 ratio; 3 mol% on total weight) was found to be best catalyst to give the desired products with excellent yields (up to 99%) in very short times (1–15 min) at room temperature in DMSO as solvent. The catalyst was recovered by adding EtOAc and reused up to 5 cycles without losing the catalytic activity.

Synthesis of spirochromene derivatives catalyzed by Mn(bpyo)2/MCM-41 in water

A three-component one-pot synthesis of spirochromene derivatives by condensing cyclic 1,3-diketones, isatin or acenaphthenequinone, and malononitrile using a catalytic amount of Mn(bpyo)2/MCM-41 in refluxing water is reported.

Protic guanidinium ionic liquid as a green and highly efficient catalyst for the synthesis of functionalized spirochromenes under solvent-free conditions

A simple and efficient method for the synthesis of functionalized spirochromenes is explained using protic guanidinium ionic liquid as a catalyst under solvent-free conditions at room temperature. This procedure is simple, clean, and excellent yields are

Novel and thermally stable ionic liquid (TBA acetate) for domino reaction: Synthesis of spirooxindoles via new mechanistic way

A simple, efficient and environmentally benign method for the one-pot, three component synthesis of spirooxindoles under task-specific novel ionic liquid Tetrabutylammonium acetate (TBA acetate) mediated and catalyzed conditions is described involving isa

Greener synthesis of spirooxindole in deep eutectic solvent

A simple and efficient synthesis of spirooxindole derivatives by one-pot, three-component reaction of isatins, malononitrile and different nucleophiles under catalyst-free condition in deep eutectic solvent is reported. A series of biological importance, spirooxindole derivatives were synthesized via a multicomponent reaction of isatin, or acenaphthoquinone, and malononitrile or cyanoacetic ester with 1,3-dicarbonyl compounds, naphtol and 4-hydroxycumarin in biodegradable choline chloride based deep eutectic solvent in good yields (50-95%). This green procedure has the advantages of higher yields, shorter reaction times, environmental friendliness, and easy work-up.

Carbon-SO3H: A novel and recyclable solid acid catalyst for the synthesis of spiro[4H-pyran-3,3′-oxindoles]

A bioglycerol derived carbon-sulfonic acid is found to catalyze efficiently the three-component one-pot condensation of isatin, malononitrile, and 1,3-dicarbonyls to afford a wide range of spiro[4H-pyran-3,3′-oxindole] derivatives in good yields and selec