21025-06-9Relevant academic research and scientific papers
Synthesis of 1,3-disubstituted cyclohexenes from dienylethers: Via sequential hydrozirconation/deoxygenative cyclisation
Payet, Amandine,Blondeau, Benjamin,Behr, Jean-Bernard,Vasse, Jean-Luc
, p. 798 - 802 (2019/02/01)
Access to 1,3-disubstituted cyclohexenes from zirconocenes containing a latent electrophilic allylic fragment is described. Requiring a specific conformation, 6-endo-trig cyclisation is based on the TMSOTf-mediated generation of a stabilized carbocation.
Copper-catalyzed alkene arylation with diaryliodonium salts
Phipps, Robert J.,McMurray, Lindsay,Ritter, Stefanie,Duong, Hung A.,Gaunt, Matthew J.
supporting information; experimental part, p. 10773 - 10776 (2012/08/07)
Alkenes and arenes represent two classes of feedstock compounds whose union has fundamental importance to synthetic organic chemistry. We report a new approach to alkene arylation using diaryliodonium salts and Cu catalysis. Using a range of simple alkenes, we have shown that the product outcomes differ significantly from those commonly obtained by the Heck reaction. We have used these insights to develop a number of new tandem and cascade reactions that transform readily available alkenes into complex arylated products that may have broad applications in chemical synthesis.
