2103-49-3Relevant academic research and scientific papers
Method for Producing 2-aminobiphenylene
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Page/Page column 9, (2011/12/14)
The present invention relates to a process for preparing 2-aminobiphenyls of the formula I in which n is 0, 1, 2 or 3,R1 is hydrogen, cyano or fluorine, andeach R2 is independently selected from cyano, fluorine, C1-C4
A Versatile New Synthesis of Quinolines and Related Fused Pyridines. Part 5. The Synthesis of 2-Chloroquinoline-3-carbaldehydes
Meth-Cohn, Otto,Narine, Bramha,Tarnowski, Brian
, p. 1520 - 1530 (2007/10/02)
Acetanilides are converted into 2-chloroquinoline-3-carbaldehydes in good yield by the action of Vilsmeier's reagent in phosphoryl chloride solution.The reaction is shown to involve successive conversion of the acetanilide into an imidoyl chloride and then an N-(α-chlorovinyl)aniline.The latter enamine is diformylated at its β-position and subsequently cyclised to the chloroquinolinecarbaldehyde.The diformylated intermediates may be isolated in several cases and separately cyclised with polyphosphoric acid.
