210307-54-3Relevant academic research and scientific papers
Comparative reactivity of palladium(0) complexes generated in situ in mixtures of triphenylphosphine or tri-2-furylphosphine and Pd(dba)2
Amatore, Christian,Jutand, Anny,Meyer, Gilbert,Atmani, Hamid,Khalil, Fouad,Chahdi, Fouad Ouazzani
, p. 2958 - 2964 (2008/10/08)
For PPh3, mixtures of Pd(dba)2 and nTFP (TFP = tri-2-furylphosphine, n ≥ 2) in DMF and THF (S) lead to the formation of Pd(dba)(TFP)2, SPd(TFP)3 in equilibrium with SPd-(TFP)2. The substitution of dba by the phosphine in Pd(dba)L2 to form SPdL3 is easier for L = TPF than for L = PPh3. The less ligated complex SPd(TFP)2 is the reactive species in the oxidative addition with phenyl iodide. In THF, {Pd(dba)2 + nTFP}, a mixture often used as a catalyst promoter in several synthetic organic reactions, is found to be less reactive than {Pd(dba)2 + nPPh3} for small values of n (n = 2 or 4) whereas it is more reactive for higher values of n (n > 6). Conversely, in DMF, {Pd(dba)2 + nTFP} is always found to be more reactive than {Pd(dba)2 + nPPh3} whatever n (n ≥ 2).
